{"id":20944,"date":"2014-12-24T09:21:00","date_gmt":"2014-12-24T08:21:00","guid":{"rendered":"https:\/\/www.opc.cat\/consiguen-regenerar-pelo-modificando-celulas-del-sistema-inmune-2\/"},"modified":"2014-12-24T09:21:00","modified_gmt":"2014-12-24T08:21:00","slug":"consiguen-regenerar-pelo-modificando-celulas-del-sistema-inmune-2","status":"publish","type":"post","link":"https:\/\/www.opc.cat\/es\/consiguen-regenerar-pelo-modificando-celulas-del-sistema-inmune-2\/","title":{"rendered":"Consiguen regenerar pelo modificando c\u00e9lulas del sistema inmune"},"content":{"rendered":"<p>Investigar si es posible recuperar el cabello parece tarea exclusiva del \u00e1mbito de la est\u00e9tica, pero no lo es. El hallazgo que publica ahora un grupo del Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO) desvela claves para hacer crecer el pelo, pero adem\u00e1s aporta nuevo conocimiento sobre un problema m\u00e1s amplio: c\u00f3mo se regeneran los tejidos en el organismo adulto, y en especial la piel.<\/p>\n<p>Lo que han descubierto es una conexi\u00f3n inesperada entre el sistema de defensa del cuerpo y la regeneraci\u00f3n de la piel. Seg\u00fan revelan los autores en el trabajo, publicado en PLOS Biology, las c\u00e9lulas del sistema inmune llamadas macr\u00f3fagos \u2013responsables por ejemplo de devorar posibles pat\u00f3genos\u2013, son adem\u00e1s las encargadas de activar el crecimiento de las c\u00e9lulas madre de la piel.<\/p>\n<p>Estas c\u00e9lulas madre permiten la regeneraci\u00f3n del pelo y tambi\u00e9n originan, cuando tienen fallos, el c\u00e1ncer de c\u00e9lulas escamosas. Descubrir que los macr\u00f3fagos las activan puede ser relevante no solo de cara a terapias contra la p\u00e9rdida del cabello, sino para la investigaci\u00f3n oncol\u00f3gica.<\/p>\n<p>\u201cHemos descubierto que los macr\u00f3fagos, unas c\u00e9lulas cuya funci\u00f3n principal se ha atribuido a la defensa de infecciones y reparaci\u00f3n de heridas, participan en el proceso de regeneraci\u00f3n del pelo\u201d, explica P\u00e9rez-Moreno. \u201cIncluso hemos logrado inducir el crecimiento del pelo. Es la primera evidencia que se tiene del papel de los macr\u00f3fagos en el crecimiento c\u00edclico del pelo\u201d.Los autores del trabajo son Mirna P\u00e9rez-Moreno y Donatello Castellana, del grupo de Biolog\u00eda Celular Epitelial del Programa Fundaci\u00f3n BBVA-CNIO de Biolog\u00eda Celular del C\u00e1ncer, en colaboraci\u00f3n con Ralf Paus, de las universidades de Manchester y M\u00fcnster.<\/p>\n<p><b>Evidencias preliminares<\/b><\/p>\n<p>Los investigadores no investigaron porque s\u00ed la relaci\u00f3n entre los macr\u00f3fagos y el pelo. El trabajo, iniciado hace m\u00e1s de cuatro a\u00f1os, parte de una observaci\u00f3n de P\u00e9rez-Moreno mientras analizaba otro problema. Los ratones con los que trabajaba entonces recib\u00edan un tratamiento con antiinflamatorios, que tuvo como inesperado efecto secundario la reactivaci\u00f3n del crecimiento del pelo.<\/p>\n<p>Convencida de que la explicaci\u00f3n deb\u00eda estar en el sistema inmune \u2013la inflamaci\u00f3n es una respuesta defensiva del organismo\u2013, P\u00e9rez-Moreno empez\u00f3 a experimentar con los distintos tipos de c\u00e9lulas responsables de la defensa del organismo.<\/p>\n<div>\n<br \/><img decoding=\"async\" src=\"http:\/\/www.agenciasinc.es\/var\/ezwebin_site\/storage\/images\/media\/images\/consiguen-regenerar-pelo-modificando-celulas-del-sistema-inmune_image_380\/3457889-1-esl-MX\/Consiguen-regenerar-pelo-modificando-celulas-del-sistema-inmune_image_380_imagenGaleria.jpg\" \/><\/p>\n<p>Imagen tridimensional de la piel que muestra a los fol\u00edculos pilosos (azules) rodeados por c\u00famulos de macr\u00f3fagos residentes de tejido (rojo). La comunicaci\u00f3n molecular entre los macr\u00f3fagos y las c\u00e9lulas madre del fol\u00edculo piloso regula la iniciaci\u00f3n del crecimiento de los fol\u00edculos. \/ Donatello Castellana \/ CNIO<\/p>\n<p>Detectaron entonces un fen\u00f3meno curioso: en una fase concreta del crecimiento c\u00edclico \u2013normal\u2013 del pelo, una parte de los macr\u00f3fagos muere \u2013por el proceso de muerte celular autoinducida conocido como apoptosis\u2013, y es entonces cuando el pelo empieza a crecer de nuevo. Es decir, la muerte de una parte de los macr\u00f3fagos parece ser la se\u00f1al que empuja al fol\u00edculo piloso a entrar en la siguiente etapa del ciclo.<\/p>\n<p>Los investigadores desvelaron tambi\u00e9n c\u00f3mo transmiten los macr\u00f3fagos esa se\u00f1al. Lo explica P\u00e9rez-Moreno: \u201cLa muerte de una parte de los macr\u00f3fagos estimula a los que quedan vivos para que secreten factores que activan las c\u00e9lulas madre de la piel, y promueven as\u00ed el crecimiento del pelo\u201d.<\/p>\n<p><b>Reproducir el proceso natural<\/b><\/p>\n<p>Entre estos factores que secretan los macr\u00f3fagos destacan unas prote\u00ednas llamadas Wnt. La confirmaci\u00f3n de que los macr\u00f3fagos son los responsables de la producci\u00f3n de estas prote\u00ednas es otro de los aspectos novedosos del trabajo.<\/p>\n<p>Los investigadores demostraron todo lo anterior reproduciendo artificialmente el proceso natural. Para ello utilizaron un f\u00e1rmaco inhibidor de Wnt, y al hacerlo retrasaron, como esperaban, el crecimiento del pelo. <\/p>\n<p>La posibilidad de atacar un tipo de c\u00e9lula para afectar a otra puede tener aplicaciones m\u00e1s amplias que el \u201csolo\u201d crecimiento del pelo. Adem\u00e1s, el empleo de liposomas como veh\u00edculo de medicamentos a tipos de c\u00e9lulas espec\u00edficos es una v\u00eda en experimentaci\u00f3n muy prometedora en varias patolog\u00edas, se\u00f1ala Donatello Castellana.Aunque este trabajo ha sido realizado enteramente en ratones, los investigadores creen que su hallazgo \u201cdeber\u00eda facilitar el desarrollo de nuevas estrategias terap\u00e9uticas\u201d para el tratamiento del crecimiento del cabello en humanos.<\/p>\n<p>Tambi\u00e9n consideran importantes las implicaciones para la investigaci\u00f3n en c\u00e1ncer: \u201cLas c\u00e9lulas madre de la piel se han identificado como las c\u00e9lulas que dan origen al c\u00e1ncer de c\u00e9lulas escamosas, uno de los tumores m\u00e1s frecuentes en el mundo\u201d, se\u00f1ala P\u00e9rez-Moreno. \u201cNuestro trabajo ha identificado que los macr\u00f3fagos contribuyen a regular la proliferaci\u00f3n controlada de las c\u00e9lulas madre a trav\u00e9s de la v\u00eda Wnt; quiz\u00e1s haya tumores relacionados con un desajuste en los macr\u00f3fagos que secretan Wnt\u201d.<\/p>\n<p>Desde una perspectiva m\u00e1s b\u00e1sica, el resultado se encuadra en el esfuerzo de entender c\u00f3mo se regeneran los tejidos adultos, sobre todo la piel. Y aqu\u00ed lo importante es el nuevo gran papel que desempe\u00f1an los macr\u00f3fagos.<\/p>\n<p>\u201cLa piel est\u00e1 formada por distintas estructuras, entre ellas los fol\u00edculos, que forman el pelo y se regeneran a lo largo de nuestra vida gracias a la presencia de c\u00e9lulas madre\u201d, explican los investigadores. \u201cSe conocen ya muchas de las propiedades regenerativas de estas c\u00e9lulas, y uno de los mayores logros ha sido su multiplicaci\u00f3n en cultivo para hacer transplantes y generar de nuevo el pelo. Pero uno de los retos actuales es promover el crecimiento de las c\u00e9lulas madre sin necesidad de hacer transplantes, modificando el ambiente que las rodea\u201d.<\/p>\n<p><b>Di\u00e1logo bioqu\u00edmico<\/b><\/p>\n<p>Ahora se sabe que los macr\u00f3fagos est\u00e1n entre las c\u00e9lulas esenciales en el di\u00e1logo bioqu\u00edmico que se produce en el ambiente que rodea a las c\u00e9lulas madre.<\/p>\n<p>\u201cNuestro estudio subraya la importancia de los macr\u00f3fagos como moduladores del proceso de regeneraci\u00f3n de los tejidos y remodelaci\u00f3n de los \u00f3rganos, mucho m\u00e1s all\u00e1 de su funci\u00f3n como fagocitos [c\u00e9lulas del sistema inmune]\u201d, escriben los autores en PLoS Biology.<\/p>\n<p>Entre los pr\u00f3ximos objetivos de los investigadores est\u00e1 el estudiar este proceso en humanos. Tambi\u00e9n, profundizar en qu\u00e9 clase de macr\u00f3fagos es la que activa las c\u00e9lulas madre de la piel.<\/p>\n<p>Como explica P\u00e9rez-Moreno, \u201clos macr\u00f3fagos son una poblaci\u00f3n celular muy diversa. Hace menos de diez a\u00f1os que se ha descubierto que provienen no solo de la m\u00e9dula \u00f3sea, sino tambi\u00e9n del saco vitelino desde la gestaci\u00f3n, y que incluso hay otros macr\u00f3fagos que se reproducen en los mismos tejidos. Actualmente se desconocen los or\u00edgenes de parte de los macr\u00f3fagos que residen en la piel\u201d.<\/p>\n<div style=\"text-align: right;\">\n<i>Fuente: <a href=\"http:\/\/www.agenciasinc.es\/Noticias\/Consiguen-regenerar-pelo-modificando-celulas-del-sistema-inmune\">Agencia SINC<\/a><\/i><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Investigar si es posible recuperar el cabello parece tarea exclusiva del \u00e1mbito de la est\u00e9tica, pero no lo es. El hallazgo que publica ahora un grupo del Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO) desvela claves para hacer crecer el pelo, pero adem\u00e1s aporta nuevo conocimiento sobre un problema m\u00e1s amplio: c\u00f3mo se regeneran los tejidos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":24068,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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