{"id":20988,"date":"2014-09-29T07:31:00","date_gmt":"2014-09-29T05:31:00","guid":{"rendered":"https:\/\/www.opc.cat\/un-antidoto-para-el-sentimiento-de-decepcion-2\/"},"modified":"2014-09-29T07:31:00","modified_gmt":"2014-09-29T05:31:00","slug":"un-antidoto-para-el-sentimiento-de-decepcion-2","status":"publish","type":"post","link":"https:\/\/www.opc.cat\/es\/un-antidoto-para-el-sentimiento-de-decepcion-2\/","title":{"rendered":"Un ant\u00eddoto para el sentimiento de decepci\u00f3n"},"content":{"rendered":"<div class=\"separator\" style=\"clear: both; text-align: center;\">\n<a href=\"http:\/\/s01.s3c.es\/imag\/_v0\/580x300\/6\/b\/5\/hombre-triste-getty.jpg\" imageanchor=\"1\" style=\"margin-left: 1em; margin-right: 1em;\"><img fetchpriority=\"high\" decoding=\"async\" border=\"0\" src=\"http:\/\/s01.s3c.es\/imag\/_v0\/580x300\/6\/b\/5\/hombre-triste-getty.jpg\" height=\"165\" width=\"320\" \/><\/a><\/div>\n<div class=\"separator\" style=\"clear: both; text-align: center;\">\n<\/div>\n<p>Investigadores de la Escuela de Medicina de la Universidad de California, San Diego, Estados Unidos, han identificado un mecanismo de control de un \u00e1rea del cerebro que procesa la informaci\u00f3n sensorial y emotiva que los seres humanos experimentan como \u00abdecepci\u00f3n\u00bb. El descubrimiento, que se publica en la edici\u00f3n digital de este jueves de Science, sugiere que puede ser efectivamente un ant\u00eddoto neuroqu\u00edmico para el sentimiento de decepci\u00f3n.<\/p>\n<p>\u00abLa idea de que algunas personas ven el mundo como un vaso medio vac\u00edo tiene una base qu\u00edmica en el cerebro\u00bb, afirma el autor principal de este trabajo, Roberto Malinow, profesor en el Departamento de Neurociencias y la Secci\u00f3n de Neurobiolog\u00eda de la Divisi\u00f3n de Ciencias Biol\u00f3gicas de la Universidad de California. \u00abHemos encontrado un proceso que puede amortiguar la sensibilidad del cerebro a los acontecimientos negativos de la vida\u00bb, a\u00f1ade.<\/p>\n<p>Como se cree que las personas que luchan contra la depresi\u00f3n registran las experiencias negativas con m\u00e1s fuerza que otras, los resultados del estudio tienen implicaciones para entender no s\u00f3lo por qu\u00e9 algunas personas poseen una qu\u00edmica cerebral que los predispone a la depresi\u00f3n sino tambi\u00e9n c\u00f3mo tratarla.<\/p>\n<div>\n<br \/><b>Experimientos con roedores<\/b><\/p>\n<p>Espec\u00edficamente, en los experimentos con roedores, los investigadores de UC San Diego descubrieron que las neuronas de una peque\u00f1a regi\u00f3n por encima del t\u00e1lamo conocida como la hab\u00e9nula lateral (LHB) secretan tanto un neurotransmisor excitatorio com\u00fan, el glutamato, como su opuesto, el neurotransmisor inhibidor GABA.<\/p>\n<p>Los neurotransmisores excitatorios promueven el encendido neuronal mientras que los inhibidores lo suprimen y aunque glutamato y GABA se encuentran entre dos de los neurotransmisores m\u00e1s comunes en el cerebro de los mam\u00edferos, las neuronas son generalmente especialistas, produciendo uno pero no ambos tipos de mensajeros qu\u00edmicos.<\/p>\n<p>De hecho, antes del estudio, s\u00f3lo se hab\u00edan observado otros dos sistemas en el cerebro en los que las neuronas liberan neurotransmisores excitadores e inhibitorios en una conexi\u00f3n particular en el hipocampo y en el tronco cerebral durante el desarrollo de un mapa auditivo del cerebro.<\/p>\n<p>\u00abNuestro estudio es uno de los primeros en documentar rigurosamente que la inhibici\u00f3n puede coexistir con excitaci\u00f3n en una v\u00eda cerebral\u00bb, subraya el autor principal Steven Shabel, investigador postdoctoral en el Departamento de Neurociencias y la Secci\u00f3n de Neurobiolog\u00eda de la Divisi\u00f3n de Ciencias Biol\u00f3gicas de la Universidad de California. \u00abEn nuestro caso, parece que esa v\u00eda apunta a la decepci\u00f3n\u00bb, sugiere.<\/p>\n<p>El LHB es una peque\u00f1a estructura como de n\u00f3dulo en la regi\u00f3n epit\u00e1lamo del cerebro que es cr\u00edtica para el procesamiento de una variedad de entradas de los ganglios basales, el hipot\u00e1lamo y la corteza cerebral y la transmisi\u00f3n de las respuestas codificadas (salida) al tallo cerebral, la parte antigua del cerebro que los mam\u00edferos comparten con los reptiles.<\/p>\n<p>Los experimentos con primates han demostrado que la actividad en LHB aumenta notablemente cuando los monos esperan pero no consiguen un trago de zumo de fruta u otra recompensa, por lo tanto, validando la idea de que esta regi\u00f3n es parte de la llamada ruta de la decepci\u00f3n.<\/p>\n<p>Sin embargo, se cree que el funcionamiento adecuado de LHB es importante en mucho m\u00e1s que en la decepci\u00f3n y ha sido implicado en la regulaci\u00f3n de las respuestas al dolor y una variedad de comportamientos de motivaci\u00f3n, adem\u00e1s de relacionarse con la psicosis.<br \/>Sin relaci\u00f3n entre depresi\u00f3n e hiperactividad<\/p>\n<p>En particular, la depresi\u00f3n se ha vinculado con la hiperactividad de LHB, pero hasta este estudio, los investigadores ten\u00edan poca evidencia emp\u00edrica en cuanto a c\u00f3mo se evita esta sobreestimulaci\u00f3n en individuos sanos dada la aparente falta de neuronas inhibitorias en esta regi\u00f3n del cerebro.<\/p>\n<p>\u00abEl resultado de este estudio es que la inhibici\u00f3n de esta v\u00eda viene de una inusual coliberaci\u00f3n de neurotransmisores en la hab\u00e9nula\u00bb, insiste Shabel. Los investigadores no saben por qu\u00e9 esta regi\u00f3n del cerebro se controla de esta manera, pero una hip\u00f3tesis es que permite un control m\u00e1s sutil de la se\u00f1alizaci\u00f3n que tener dos neuronas directamente contraactuando entre s\u00ed.<\/p>\n<p>Los cient\u00edficos tambi\u00e9n pudieron demostrar que las neuronas de roedores con aspectos de depresi\u00f3n humana produjeron menos GABA en relaci\u00f3n al glutamato. Cuando se dio a estos animales un antidepresivo para elevar los niveles de serotonina de su cerebro, sus niveles relativos de GABA aumentaron.<\/p>\n<p>\u00abNuestro estudio sugiere que una de las formas en que la serotonina alivia la depresi\u00f3n es reequilibrando el procesamiento cerebral de los eventos negativos de la vida con el equilibrio de glutamato y GABA en la hab\u00e9nula\u00bb, apunta Shabel. \u00abAhora podemos tener una explicaci\u00f3n neuroqu\u00edmica precisa de por qu\u00e9 los antidepresivos hacen que algunas personas sean m\u00e1s resistentes a las experiencias negativas\u00bb, concluye.<\/p>\n<div style=\"text-align: right;\">\n<i style=\"font-size: small;\">Fuente: <a href=\"http:\/\/ecodiario.eleconomista.es\/ciencia\/noticias\/6091339\/09\/14\/Un-antidoto-para-el-sentimiento-de-decepcion.html\" target=\"_blank\">El Economista<\/a><\/i><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Investigadores de la Escuela de Medicina de la Universidad de California, San Diego, Estados Unidos, han identificado un mecanismo de control de un \u00e1rea del cerebro que procesa la informaci\u00f3n sensorial y emotiva que los seres humanos experimentan como \u00abdecepci\u00f3n\u00bb. El descubrimiento, que se publica en la edici\u00f3n digital de este jueves de Science, sugiere [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":24122,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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