{"id":21060,"date":"2014-08-12T15:50:00","date_gmt":"2014-08-12T13:50:00","guid":{"rendered":"https:\/\/www.opc.cat\/bioingenieros-crean-tejido-cerebral-funcional-en-3d-2\/"},"modified":"2014-08-12T15:50:00","modified_gmt":"2014-08-12T13:50:00","slug":"bioingenieros-crean-tejido-cerebral-funcional-en-3d-2","status":"publish","type":"post","link":"https:\/\/www.opc.cat\/es\/bioingenieros-crean-tejido-cerebral-funcional-en-3d-2\/","title":{"rendered":"Bioingenieros crean tejido cerebral funcional en 3D"},"content":{"rendered":"<div class=\"separator\" style=\"clear: both; text-align: center;\">\n<a href=\"http:\/\/images.lainformacion.com\/cms\/bioingenieros-crean-tejido-cerebral-funcional-en-3d\/2014_8_12_BxKjVJTc5ULI7BfFGQefs3.jpg?width=642&amp;height=482&amp;type=height&amp;id=D9vTI4homFhKUynT8dEFa&amp;time=1407827667&amp;project=lainformacion\" imageanchor=\"1\" style=\"clear: left; float: left; margin-bottom: 1em; margin-right: 1em;\"><img fetchpriority=\"high\" decoding=\"async\" border=\"0\" src=\"http:\/\/images.lainformacion.com\/cms\/bioingenieros-crean-tejido-cerebral-funcional-en-3d\/2014_8_12_BxKjVJTc5ULI7BfFGQefs3.jpg?width=642&amp;height=482&amp;type=height&amp;id=D9vTI4homFhKUynT8dEFa&amp;time=1407827667&amp;project=lainformacion\" height=\"320\" width=\"319\" \/><\/a><\/div>\n<p>Investigadores han creado tejido cerebral tridimensional funcional con caracter\u00edsticas estructurales similares a los tejidos en el cerebro de rata y que puede mantenerse vivo en el laboratorio durante m\u00e1s de dos meses, tal y como describen en un art\u00edculo que se publica esta semana en &#8216;Proceedings of the National Academy of Sciences&#8217;.<\/p>\n<p>Como primera demostraci\u00f3n de su potencial, los cient\u00edficos emplearon el tejido cerebral para estudiar los cambios qu\u00edmicos y el\u00e9ctricos que ocurren inmediatamente despu\u00e9s de una lesi\u00f3n traum\u00e1tica del cerebro y, en un experimento separado, las modificaciones que suceden en respuesta a un f\u00e1rmaco. El tejido puede ser un modelo superior para el an\u00e1lisis de la funci\u00f3n cerebral normal, as\u00ed como lesiones y enfermedad, y ayudar en el desarrollo de nuevos tratamientos para la disfunci\u00f3n cerebral.<\/p>\n<p>El tejido cerebral se desarroll\u00f3 en el Centro de Ingenier\u00eda de Tejido en la&nbsp;Universidad de Tufts, en Boston, Estados Unidos, financiado por el Instituto Nacional de Im\u00e1genes Biom\u00e9dicas y Bioingenier\u00eda (NIBIB, por sus siglas en ingl\u00e9s) para establecer biomateriales innovadores y modelos de ingenier\u00eda de tejidos.<\/p>\n<p>Actualmente, los cient\u00edficos cultivan neuronas en placas de petri para estudiar su comportamiento en un entorno controlable, pero al ser en dos dimensiones son incapaces de replicar la compleja organizaci\u00f3n estructural del tejido cerebral, que consiste en regiones separadas de materia gris y blanca. En el cerebro, la materia gris est\u00e1 compuesta principalmente por cuerpos celulares de neuronas, mientras que la blanca est\u00e1 formada por haces de axones, que son las prolongaciones de las neuronas que conducen el impulso nervioso para conectarse unas con otras.<\/p>\n<p>Debido a que las lesiones cerebrales y las enfermedades suelen afectar a estas \u00e1reas de manera diferente, se necesitan modelos que exhiban la compartimentaci\u00f3n de la materia gris y blanca. Recientemente, ingenieros de tejidos han intentado cultivar neuronas en entornos de gel en 3-D, donde pueden establecer libremente conexiones en todas las direcciones, pero estos modelos de tejidos a base de gel no viven mucho tiempo y dejan de producir la funci\u00f3n a nivel de tejido robusto.<\/p>\n<p>Esto es porque el ambiente extracelular es una matriz compleja en la que las se\u00f1ales locales establecen diferentes entornos que estimulan distinto crecimiento celular y\/o desarrollo y funci\u00f3n, de forma que no es suficiente proporcionar simplemente el espacio para que las neuronas crezcan en tres dimensiones. Ahora, un grupo de bioingenieros informa que han creado con \u00e9xito tejido cerebral funcional en 3-D que presenta compartimentaci\u00f3n de materia blanca y gris y puede sobrevivir en el laboratorio durante m\u00e1s de dos meses.<\/p>\n<p>\u00abEste trabajo es un logro excepcional &#8211;afirma Rosemarie Hunziker, directora del programa de Ingenier\u00eda de Tejidos en NIBIB&#8211;. Combina una profunda comprensi\u00f3n de la fisiolog\u00eda del cerebro con un conjunto grande y creciente de herramientas de bioingenier\u00eda para crear un ambiente que es a la vez necesario y suficiente para imitar la funci\u00f3n del cerebro\u00bb.<\/p>\n<p>La clave para generar tejido similar al cerebral fue la creaci\u00f3n de una nueva estructura compuesta que consiste en dos biomateriales con propiedades f\u00edsicas diferentes: un andamio esponjoso hecho de prote\u00edna de seda y un gel a base de col\u00e1geno m\u00e1s suave. El andamio sirve como una estructura en la que las neuronas pueden anclarse y el gel alienta a los axones a crecer a trav\u00e9s de \u00e9l.<\/p>\n<p>Para lograr esa divisi\u00f3n en materia gris y blanca, estos expertos cortaron el andamio esponjoso en forma de donut y lo poblaron con neuronas de rata, llenando as\u00ed el centro de la rosquilla con el gel a base de col\u00e1geno, que posteriormente impregn\u00f3 el andamio. En pocos d\u00edas, las neuronas formaron redes funcionales alrededor de los poros del andamio y enviaron largas proyecciones del ax\u00f3n a trav\u00e9s del centro del gel para conectar con las neuronas en el lado opuesto de la rosquilla.<\/p>\n<p>El resultado fue una regi\u00f3n distinta de materia blanca, que contiene en su mayor\u00eda proyecciones celulares, los axones, formados en el centro de la rosquilla que estaba separada de la materia gris circundante, donde se concentraron los cuerpos celulares. Durante un periodo de varias semanas, los expertos llevaron a cabo experimentos para determinar la salud y la funci\u00f3n de las neuronas que crecen en el tejido cerebral en 3-D y para compararlas con las cultivadas s\u00f3lo en un entorno de gel col\u00e1geno o en un plato en 2-D.<\/p>\n<p>Entonces, encontraron que las neuronas en los tejidos del cerebro fabricados en 3-D tuvieron mayor expresi\u00f3n de genes implicados en el crecimiento y la funci\u00f3n de las neuronas. Adem\u00e1s, las neuronas cultivadas en el tejido cerebral 3-D mantienen la actividad metab\u00f3lica estable durante hasta cinco semanas, mientras que la salud de las neuronas cultivadas en el medio ambiente de gel comienzan a deteriorarse a las 24 horas.<\/p>\n<p>En lo que respecta a la funci\u00f3n, las neuronas en el tejido cerebral 3-D exhibieron actividad el\u00e9ctrica y capacidad de respuesta al imitar las se\u00f1ales observadas en el cerebro intacto, incluyendo un patr\u00f3n de respuesta electrofisiol\u00f3gico t\u00edpico de una neurotoxina. Como el tejido cerebral 3-D muestra propiedades f\u00edsicas similares al tejido cerebral de roedores, los expertos trataron de determinar si pueden usarlo para estudiar la lesi\u00f3n cerebral traum\u00e1tica.<\/p>\n<p>Para simular una lesi\u00f3n cerebral traum\u00e1tica, se deja caer un peso sobre el tejido cerebral en 3-D desde distintas alturas y luego se miden los cambios en la actividad el\u00e9ctrica y qu\u00edmica de las neuronas, provocando efectos similares a los observados habitualmente en estudios de lesi\u00f3n cerebral traum\u00e1tica en animales. \u00abCon este sistema, se puede hacer un seguimiento de la respuesta de los tejidos a la lesi\u00f3n cerebral traum\u00e1tica en tiempo real &#8211;apunta David Kaplan, profesor de Ingenier\u00eda de la Universidad de Tufts&#8211;. Tambi\u00e9n es posible seguir la reparaci\u00f3n y lo que ocurre en periodos m\u00e1s largos de tiempo\u00bb.<\/p>\n<p>Kaplan destac\u00f3 la importancia de la longevidad de los tejidos del cerebro dise\u00f1ados en 3-D para la investigaci\u00f3n de otros trastornos cerebrales. \u00abEl hecho de que podamos mantener este tejido durante meses en el laboratorio significa que podemos empezar a mirar las enfermedades neurol\u00f3gicas en formas que de otra manera no es posible porque se necesitan plazos largos para estudiar algunas de las enfermedades cerebrales clave\u00bb, afirma.<\/p>\n<p>\u00abLos buenos modelos permiten hip\u00f3tesis s\u00f3lidas que pueden ser probadas a fondo. La esperanza es que el uso de este modelo pueda conducir a una aceleraci\u00f3n de los tratamientos para la disfunci\u00f3n cerebral, as\u00ed como ofrecer una mejor manera de estudiar la fisiolog\u00eda normal del cerebro\u00bb, agrega Hunziker.<\/p>\n<p>En este trabajo, estos cient\u00edficos demostraron que pueden modificar su andamio de rosquilla porque se compone de seis anillos conc\u00e9ntricos, cada uno capaz de ser poblado con diferentes tipos de neuronas. Ese tipo de disposici\u00f3n imita las seis capas de la corteza cerebral humana en la que existen diferentes tipos de neuronas.<\/p>\n<div>\n<\/div>\n<div style=\"text-align: right;\">\n<i>Fuente: <a href=\"http:\/\/noticias.lainformacion.com\/salud\/genetica\/bioingenieros-crean-tejido-cerebral-funcional-en-3d_iVuxoKKdpTXxPnJlfHQwa3\/\" target=\"_blank\">La Informaci\u00f3n<\/a><\/i><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Investigadores han creado tejido cerebral tridimensional funcional con caracter\u00edsticas estructurales similares a los tejidos en el cerebro de rata y que puede mantenerse vivo en el laboratorio durante m\u00e1s de dos meses, tal y como describen en un art\u00edculo que se publica esta semana en &#8216;Proceedings of the National Academy of Sciences&#8217;. Como primera demostraci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":24209,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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