{"id":21062,"date":"2014-08-11T15:46:00","date_gmt":"2014-08-11T13:46:00","guid":{"rendered":"https:\/\/www.opc.cat\/nueva-via-de-prevencion-del-ictus-con-genetica-y-dieta-mediterranea-2\/"},"modified":"2014-08-11T15:46:00","modified_gmt":"2014-08-11T13:46:00","slug":"nueva-via-de-prevencion-del-ictus-con-genetica-y-dieta-mediterranea-2","status":"publish","type":"post","link":"https:\/\/www.opc.cat\/es\/nueva-via-de-prevencion-del-ictus-con-genetica-y-dieta-mediterranea-2\/","title":{"rendered":"Nueva v\u00eda de prevenci\u00f3n del ictus con gen\u00e9tica y dieta mediterr\u00e1nea"},"content":{"rendered":"<div class=\"separator\" style=\"clear: both; text-align: center;\">\n<a href=\"http:\/\/noticiasdelaciencia.com\/upload\/img\/periodico\/img_21626.jpg\" imageanchor=\"1\" style=\"margin-left: 1em; margin-right: 1em;\"><img decoding=\"async\" border=\"0\" src=\"http:\/\/noticiasdelaciencia.com\/upload\/img\/periodico\/img_21626.jpg\" \/><\/a><\/div>\n<p>Miembros del Centro de Investigaci\u00f3n Biom\u00e9dica en Red-Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n (CIBERobn), dependiente del Instituto de Salud Carlos III, en Espa\u00f1a, han descubierto el efecto protector de un polimorfismo (variaci\u00f3n en la secuencia de una zona del ADN en individuos de una poblaci\u00f3n) llamado rs13702 T&gt; en el riesgo de padecer un ictus cerebral, as\u00ed como su modulaci\u00f3n a trav\u00e9s de la dieta. El polimorfismo est\u00e1 regulado por el microARN-410.<\/p>\n<p>\u00abEstos resultados tienen una gran relevancia porque por primera vez hemos demostrado la implicaci\u00f3n de los microARN, a trav\u00e9s de sus lugares de uni\u00f3n al ADN, en los mecanismos protectores de la dieta mediterr\u00e1nea y hemos puesto de manifiesto la compleja regulaci\u00f3n geno-epigen\u00f3mica de estos efectos\u00bb, se\u00f1ala Dolores Corella, que ha liderado el trabajo en colaboraci\u00f3n con el investigador Jos\u00e9 Mar\u00eda Ordov\u00e1s del Human Nutrition Research Center de Boston.<\/p>\n<p>Corella destaca estos resultados, generados en el marco de un ensayo de intervenci\u00f3n diet\u00e9tica, como \u201cpioneros a nivel mundial\u201d. Desde su punto de vista \u201caportan un alto nivel de evidencia cient\u00edfica, contribuyendo a crear conocimiento nuevo y m\u00e1s s\u00f3lido sobre mecanismos y bases moleculares que nos permitir\u00e1n avanzar en el dise\u00f1o de dietas m\u00e1s personalizadas\u201d.<\/p>\n<p>El estudio se ha realizado partiendo de un trabajo previo del grupo de Ordov\u00e1s, en el que se hab\u00eda caracterizado de manera muy extensa la funcionalidad del microARN-410 y su asociaci\u00f3n con los triglic\u00e9ridos. El objetivo de la investigaci\u00f3n actual era demostrar que el polimorfismo rs13702 T&gt;C en el lugar de uni\u00f3n del microARN en el gen de la lipoproteinlipasa, no s\u00f3lo se asocia con los triglic\u00e9ridos de manera transversal, sino que se puede modular por la alimentaci\u00f3n, dentro de un estudio de intervenci\u00f3n diet\u00e9tica a largo plazo como es el PREDIMED (prevenci\u00f3n con dieta mediterr\u00e1nea).<\/p>\n<p>Adem\u00e1s, se observa un efecto sobre otros marcadores de estr\u00e9s oxidativo y sobre las enfermedades cardiovasculares. Estos resultados han sido publicados recientemente en la versi\u00f3n electr\u00f3nica de la revista American Journal of Clinical Nutrition.<\/p>\n<p>Despu\u00e9s de una media de 5 a\u00f1os de intervenci\u00f3n con dieta mediterr\u00e1nea, bien suplementada con aceite de oliva o con frutos secos en los 7.187 participantes del estudio PREDIMED, se compararon los resultados para las personas con genotipo TT (que permite la uni\u00f3n del microARN-410 y son un 45% de la poblaci\u00f3n) frente a las portadoras del alelo favorable C (un 55%), que bloquea la uni\u00f3n del microARN-410 y activa el gen de la lipoproteinlipasa, una enzima que act\u00faa como protector cardiovascular.<\/p>\n<div>\nSe comprob\u00f3 que el polimorfismo analizado se asocia con un menor riesgo de ictus cerebral en las personas portadoras del alelo C, en comparaci\u00f3n con las personas con el genotipo TT. Este efecto protector se estim\u00f3 en un 26% de reducci\u00f3n global del riesgo de ictus en los portadores de la variante favorable C.<\/p>\n<p>Paralelamente, se constat\u00f3 que la dieta mediterr\u00e1nea influ\u00eda de manera muy significativa en los efectos del polimorfismo tanto sobre el ictus como sobre los triglic\u00e9ridos. Solamente cuando los portadores del alelo favorable C segu\u00edan una dieta mediterr\u00e1nea se observ\u00f3 que el efecto de protecci\u00f3n frente a ictus era estad\u00edsticamente significativo.<\/p><\/div>\n<div>\nEn ellos la reducci\u00f3n del riesgo alcanz\u00f3 un 42% de protecci\u00f3n. Sin embargo en los portadores del alelo C que no segu\u00edan una dieta mediterr\u00e1nea el efecto protector gen\u00e9tico s\u00f3lo fue del 6%, sin alcanzar la significaci\u00f3n estad\u00edstica. De esto se puede concluir que el factor protector inherente a la variante C se pierde con una dieta inadecuada.<\/p>\n<p>El estudio registr\u00f3 otra interacci\u00f3n gen-dieta en la protecci\u00f3n que ejerce el polimorfismo rs13702 frente a la hipertrigliceridemia en funci\u00f3n del tipo de alimentaci\u00f3n. Al igual que en el caso del ictus, la reducci\u00f3n de triglic\u00e9ridos fue mayor en las personas portadoras del alelo C y que siguieron una dieta mediterr\u00e1nea.<\/p>\n<p>Investigaciones precedentes han situado a los microARN como importantes reguladores epigen\u00e9ticos (factores no gen\u00e9ticos) en las enfermedades cardiovaculares. Este estudio aporta nuevos conocimientos sobre su regulaci\u00f3n tanto gen\u00e9tica como epigen\u00e9tica, es decir, tanto prestando atenci\u00f3n a la secuencia del ADN como a los procesos qu\u00edmicos que modifican la actividad del ADN pero sin alterar su secuencia.<\/p>\n<p>En este caso concreto los investigadores explican que adem\u00e1s del microARN hay que tener en cuenta el genoma de la persona, pues en funci\u00f3n del genotipo el microARN ejercer\u00e1 o no su efecto modulador. Asimismo, esta investigaci\u00f3n aporta nuevos datos de c\u00f3mo se pueden usar los microARN en prevenci\u00f3n y tratamiento, con resultados pioneros sobre su modulaci\u00f3n a trav\u00e9s de la dieta.<\/p>\n<div style=\"text-align: right;\">\n<i>Fuente: <a href=\"http:\/\/noticiasdelaciencia.com\/not\/11140\/nueva-via-de-prevencion-del-ictus-con-genetica-y-dieta-mediterranea\/es\/\" target=\"_blank\">Noticias de la Ciencia y la Tecnolog\u00eda<\/a><\/i><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Miembros del Centro de Investigaci\u00f3n Biom\u00e9dica en Red-Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n (CIBERobn), dependiente del Instituto de Salud Carlos III, en Espa\u00f1a, han descubierto el efecto protector de un polimorfismo (variaci\u00f3n en la secuencia de una zona del ADN en individuos de una poblaci\u00f3n) llamado rs13702 T&gt; en el riesgo de padecer un [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":24212,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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