{"id":21148,"date":"2014-06-25T05:06:00","date_gmt":"2014-06-25T03:06:00","guid":{"rendered":"https:\/\/www.opc.cat\/descubren-una-proteina-que-permite-a-las-celulas-madre-del-cerebro-generar-neuronas-nuevas-2\/"},"modified":"2014-06-25T05:06:00","modified_gmt":"2014-06-25T03:06:00","slug":"descubren-una-proteina-que-permite-a-las-celulas-madre-del-cerebro-generar-neuronas-nuevas-2","status":"publish","type":"post","link":"https:\/\/www.opc.cat\/es\/descubren-una-proteina-que-permite-a-las-celulas-madre-del-cerebro-generar-neuronas-nuevas-2\/","title":{"rendered":"Descubren una prote\u00edna que permite a las c\u00e9lulas madre del cerebro generar neuronas nuevas"},"content":{"rendered":"<div class=\"separator\" style=\"clear: both; text-align: center;\">\n<a href=\"http:\/\/img02.lavanguardia.com\/2014\/06\/24\/Ilustracion-de-una-neurona-y-s_54410343263_51351706917_600_226.jpg\" imageanchor=\"1\" style=\"clear: left; float: left; margin-bottom: 1em; margin-right: 1em;\"><img decoding=\"async\" border=\"0\" src=\"http:\/\/img02.lavanguardia.com\/2014\/06\/24\/Ilustracion-de-una-neurona-y-s_54410343263_51351706917_600_226.jpg\" height=\"120\" width=\"320\" \/><\/a><\/div>\n<p>Un equipo de investigadores de la Unidad de Neurobiolog\u00eda Molecular de la Universitat de Val\u00e8ncia (UV), dirigidos por la catedr\u00e1tica de Biolog\u00eda Celular Isabel Fari\u00f1as, acaba de publicar en la revista <a href=\"http:\/\/www.nature.com\/ncb\/index.html\">Nature Cell Biology<\/a> los resultados de un trabajo que podr\u00eda arrojar luz sobre el programa normal de activaci\u00f3n de las c\u00e9lulas madre del cerebro adulto para producir nuevas neuronas a lo largo de toda la vida.<\/p>\n<p>Seg\u00fan han explicado desde la instituci\u00f3n acad\u00e9mica en un comunicado, los tejidos se renuevan constantemente gracias a las c\u00e9lulas madre, que generan nuevas c\u00e9lulas para sustituir a las c\u00e9lulas viejas. Estas c\u00e9lulas madre se localizan en ubicaciones muy concretas dentro de los tejidos, que se conocen como microambientes o nichos y en los que las c\u00e9lulas madre se relacionan con otros tipos de c\u00e9lulas. Aunque la regulaci\u00f3n de estas interacciones celulares es poco conocida en general, las c\u00e9lulas madre del cerebro adulto est\u00e1n adheridas a otras c\u00e9lulas de su nicho por una prote\u00edna de adhesi\u00f3n celular llamada N-cadherin, que act\u00faa como lazo.<\/p>\n<p>En este estudio de investigadores de la UV, realizado en ratones, se ha demostrado que existe una prote\u00edna, llamada MT5-MMP, que es capaz de cortar este lazo liberando as\u00ed a las c\u00e9lulas madre del control del nicho. \u00abEl trabajo nos permite conocer mejor las relaciones entre las c\u00e9lulas madre y su entorno e identifica dianas moleculares sobre las que poder actuar para potenciar la activaci\u00f3n de estas c\u00e9lulas durante la renovaci\u00f3n de los tejidos o en procesos regenerativos\u00bb, ha afirmado Eva Porlan, primera autora del trabajo.<\/p>\n<p>Por otro lado, es \u00abimportante\u00bb tener en cuenta que la activaci\u00f3n descontrolada de las c\u00e9lulas madre \u00abpuede dar lugar a tumores\u00bb, ha indicado Fari\u00f1as. Por ello, este trabajo \u00abest\u00e1 vinculado a otros aspectos de nuestra investigaci\u00f3n orientados a la comprensi\u00f3n de c\u00f3mo se controla la activaci\u00f3n normal de las c\u00e9lulas madre, a fin de encontrar soluciones terap\u00e9uticas a la formaci\u00f3n de tumores causados por la p\u00e9rdida de dicho control\u00bb, ha a\u00f1adido.<\/p>\n<p>Con todo ello, la neurobiolog\u00eda desarrollada en la UV aporta, una vez m\u00e1s, nuevos datos al estudio y avance de la medicina regenerativa, un campo de la ciencia que busca soluciones terap\u00e9uticas basadas en las c\u00e9lulas madre para procesos degenerativos, como puedan ser el Alzheimer o el Parkinson.<\/p>\n<p>Esta investigaci\u00f3n sale publicada en el n\u00famero de julio de la revista cient\u00edfica Nature Cell Biology y, en ella, el equipo de la Universitat ha contado con la colaboraci\u00f3n de los equipos de Antonella Consiglio del Institut de Biomedicina de la Universitat de Barcelona (IBUB), de Carlos L\u00f3pez-Ot\u00edn de la Universidad de Oviedo, y de Robert Kypta del CIC bioGUNE de Bilbao.<\/p>\n<p>El equipo de Fari\u00f1as pertenece a la Unidad de Neurobiolog\u00eda Molecular del Departamento de Biolog\u00eda Celular y Parasitolog\u00eda y a la ERI de Biotecnolog\u00eda y Biomedicina de la Universitat, al Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED) y a la RETIC de Terapia Celular del Instituto de Salud Carlos III, y es grupo Prometeo de excelencia de la Generalitat Valenciana.<\/p>\n<div style=\"text-align: right;\">\n<i>Fuente: <a href=\"http:\/\/www.lavanguardia.com\/vida\/20140624\/54410252117\/descubren-proteina-celulas-madre-cerebro-neuronas-nuevas.html\" target=\"_blank\">La Vanguardia<\/a><\/i><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Un equipo de investigadores de la Unidad de Neurobiolog\u00eda Molecular de la Universitat de Val\u00e8ncia (UV), dirigidos por la catedr\u00e1tica de Biolog\u00eda Celular Isabel Fari\u00f1as, acaba de publicar en la revista Nature Cell Biology los resultados de un trabajo que podr\u00eda arrojar luz sobre el programa normal de activaci\u00f3n de las c\u00e9lulas madre del cerebro [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":24341,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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