{"id":21200,"date":"2014-03-13T10:10:00","date_gmt":"2014-03-13T09:10:00","guid":{"rendered":"https:\/\/www.opc.cat\/un-estudio-con-participacion-espanola-resuelve-el-enigma-hereditario-de-la-obesidad-2\/"},"modified":"2014-03-13T10:10:00","modified_gmt":"2014-03-13T09:10:00","slug":"un-estudio-con-participacion-espanola-resuelve-el-enigma-hereditario-de-la-obesidad-2","status":"publish","type":"post","link":"https:\/\/www.opc.cat\/es\/un-estudio-con-participacion-espanola-resuelve-el-enigma-hereditario-de-la-obesidad-2\/","title":{"rendered":"Un estudio con participaci\u00f3n espa\u00f1ola resuelve el enigma hereditario de la obesidad"},"content":{"rendered":"<div class=\"separator\" style=\"clear: both; text-align: center;\">\n<a href=\"https:\/\/www.opc.cat\/wp-content\/uploads\/2014\/03\/obesidad.jpg\" imageanchor=\"1\" style=\"clear: right; float: right; margin-bottom: 1em; margin-left: 1em;\"><img fetchpriority=\"high\" decoding=\"async\" border=\"0\" src=\"https:\/\/www.opc.cat\/wp-content\/uploads\/2014\/03\/obesidad.jpg\" height=\"206\" width=\"320\" \/><\/a><\/div>\n<p>Las mutaciones en el gen FTO se han considerado los determinantes gen\u00e9ticos m\u00e1s relevantes en el riesgo de obesidad en los seres humanos, pero se desconoc\u00eda el mecanismo que hab\u00eda tras esta relaci\u00f3n. Ahora, un equipo internacional de cient\u00edficos, con participaci\u00f3n espa\u00f1ola, ha descubierto que los elementos asociados a la obesidad de FTO interact\u00faan con Irx3, que parece ser el gen funcional de la obesidad.<\/p>\n<p>Esto indicar\u00eda que, por s\u00ed mismo, el gen FTO s\u00f3lo tiene un efecto perif\u00e9rico sobre la obesidad, seg\u00fan las conclusiones de este trabajo, que publica Nature. \u00abNuestros datos sugieren que Irx3 controla la masa corporal y regula la composici\u00f3n del cuerpo\u00bb, afirma el autor principal del estudio, Marcelo Nobrega, profesor asociado de Gen\u00e9tica Humana en la Universidad de Chicago, en Estados Unidos. \u00abCualquier asociaci\u00f3n entre FTO y la obesidad parece que se debe a la influencia de Irx3\u00bb, agrega el investigador.<\/p>\n<p>Se han estudiado ampliamente las mutaciones en los intrones (porciones no codificantes del ADN) del gen FTO despu\u00e9s de que las investaciones de asociaci\u00f3n del genoma revelaran una fuerte relaci\u00f3n entre FTO, la obesidad y la diabetes. Sin embargo, la sobreexpresi\u00f3n o eliminaci\u00f3n de FTO en modelos animales afecta a toda la masa corporal, no s\u00f3lo a la grasa, y los experimentos no han podido demostrar que estos intrones relacionados con la obesidad afectan a la funci\u00f3n en s\u00ed del gen FTO.<\/p>\n<p>Nobrega y su equipo descubrieron que el promotor que activa FTO no interacciona con intrones FTO asociados a la obesidad. \u00abEn su lugar, vimos que el promotor de Irx3, un gen a varios cientos de miles de pares de bases de distancia, se relaciona con estos intrones, as\u00ed como con un gran n\u00famero de otros elementos a lo largo del gran tramo gen\u00e9tico que estudiamos\u00bb, relata el coautor Jos\u00e9 Luis G\u00f3mez-Sk\u00e1rmeta, genetista en el Centro de Biolog\u00eda del Desarrollo en Sevilla, Espa\u00f1a. Los cient\u00edficos hallaron un patr\u00f3n similar de interacciones en los seres humanos despu\u00e9s de analizar los datos del proyecto ENCODE, que se confirmaron con experimentos en c\u00e9lulas humanas.<\/p>\n<p>As\u00ed, y a partir de 153 muestras de cerebro de personas de ascendencia europea, los investigadores observaron que las mutaciones en los intrones FTO que afectaron al peso corporal se asocian con la expresi\u00f3n Irx3, pero no con FTO. Los intrones de FTO relacionados con la obesidad aumentaron la expresi\u00f3n de Irx3, operando como elementos reguladores, por lo que el gen FTO en s\u00ed no parece desempe\u00f1ar funci\u00f3n alguna en esta interacci\u00f3n.<\/p>\n<p>\u00abLos elementos reguladores son los interruptores que activan genes dentro y fuera. Lo que hemos encontrado es que los interruptores que controlan Irx3 est\u00e1n lejos del gen y dentro del gen FTO\u00bb, matiza Nobrega. Para verificar el papel de Irx3, los expertos dise\u00f1aron ratones sin ese gen, con un peso un 30 por ciento inferior al de los ejemplares normales debido a que ten\u00edan menos grasa.<\/p>\n<p>Cuando se les aliment\u00f3 con una dieta alta en grasa, los ratones sin Irx3 conservaron el mismo peso e iguales niveles de grasa que con las dietas normales, mientras que los roedores normales alimentados con una dieta alta en grasas ganaron casi el doble de peso. Las c\u00e9lulas de grasa en ratones deficientes de Irx3 eran m\u00e1s peque\u00f1as y no se observaron mayores niveles de grasa marr\u00f3n, adem\u00e1s de que estos animales eran m\u00e1s capaces de procesar la glucosa.<\/p>\n<p><b>Funci\u00f3n Irx3 alterada en el hipot\u00e1lamo<\/b><\/p>\n<p>\u00abEstos ratones est\u00e1n delgados. Pierden peso principalmente por la p\u00e9rdida de grasa. Pero no son enanos\u00bb, afirma el coautor Chin-Chung Hui, profesor de Gen\u00e9tica Molecular en la Universidad de Toronto, Canad\u00e1. \u00abTambi\u00e9n son completamente resistentes al alto contenido de grasa de las dietas que llevan a la obesidad. Tienen mucho mejor capacidad para manejar la glucosa y parecen protegidos contra la diabetes\u00bb, resume.<\/p>\n<p>Los investigadores tambi\u00e9n vieron que los ratones con la funci\u00f3n Irx3 alterada en el hipot\u00e1lamo, la parte del cerebro conocida por regular el comportamiento relativo a la alimentaci\u00f3n y el gasto de energ\u00eda, mostraron un patr\u00f3n id\u00e9ntico de delgadez al de los ratones que carec\u00edan por completo de este gen. Por lo tanto, la funci\u00f3n de Irx3 en el hipot\u00e1lamo parece controlar la masa corporal y la composici\u00f3n en estos animales, lo que indica que la predisposici\u00f3n gen\u00e9tica a la obesidad est\u00e1 conectada en el cerebro.<\/p>\n<p>Irx3 codifica una prote\u00edna que regula otros genes y est\u00e1 presente tanto dentro como fuera del cerebro, en \u00f3rganos y c\u00e9lulas como las de la grasa. Nobrega y su equipo est\u00e1n investigando c\u00f3mo Irx3 interact\u00faa con los genes y las mol\u00e9culas que regula con la esperanza de identificar objetivos para desarrollar nuevas terapias contra la obesidad y la diabetes.<\/p>\n<p>\u00abIrx3 es probablemente un regulador maestro de los programas gen\u00e9ticos en las c\u00e9lulas donde se expresa\u00bb, subraya Nobrega. \u00abEstamos muy interesados ??en saber cu\u00e1les son sus objetivos y qu\u00e9 alteran. La intenci\u00f3n es identificar dianas de Irx3 que se conviertan en modelos para el dise\u00f1o de f\u00e1rmacos\u00bb, concluye este investigador.<\/p>\n<div>\n<\/div>\n<div style=\"text-align: right;\">\nFuente:<a href=\"http:\/\/www.jano.es\/jano\/actualidad\/ultimas\/noticias\/janoes\/estudio\/participacion\/espanola\/resuelve\/enigma\/hereditario\/obesidad\/_f-11+iditem-21662+idtabla-1\" target=\"_blank\"> Jano<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Las mutaciones en el gen FTO se han considerado los determinantes gen\u00e9ticos m\u00e1s relevantes en el riesgo de obesidad en los seres humanos, pero se desconoc\u00eda el mecanismo que hab\u00eda tras esta relaci\u00f3n. Ahora, un equipo internacional de cient\u00edficos, con participaci\u00f3n espa\u00f1ola, ha descubierto que los elementos asociados a la obesidad de FTO interact\u00faan con [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":24452,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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