{"id":21230,"date":"2013-11-13T12:14:00","date_gmt":"2013-11-13T11:14:00","guid":{"rendered":"https:\/\/www.opc.cat\/investigadores-espanoles-desarrollan-la-primera-vacuna-de-origen-humano-para-la-tuberculosis-2\/"},"modified":"2013-11-13T12:14:00","modified_gmt":"2013-11-13T11:14:00","slug":"investigadores-espanoles-desarrollan-la-primera-vacuna-de-origen-humano-para-la-tuberculosis-2","status":"publish","type":"post","link":"https:\/\/www.opc.cat\/es\/investigadores-espanoles-desarrollan-la-primera-vacuna-de-origen-humano-para-la-tuberculosis-2\/","title":{"rendered":"Investigadores espa\u00f1oles desarrollan la primera vacuna de origen humano para la tuberculosis"},"content":{"rendered":"<div class=\"separator\" style=\"clear: both; text-align: center;\">\n<a href=\"http:\/\/3.bp.blogspot.com\/-Vwng89Q8Ot4\/UoNtIxYk4tI\/AAAAAAAAAMo\/HFsnxy4Lrxs\/s1600\/vacuna-tuberculosis.jpg\" imageanchor=\"1\" style=\"clear: left; float: left; margin-bottom: 1em; margin-right: 1em;\"><img fetchpriority=\"high\" decoding=\"async\" border=\"0\" height=\"174\" src=\"https:\/\/www.opc.cat\/wp-content\/uploads\/2013\/11\/vacuna-tuberculosis.jpg\" width=\"320\" \/><\/a><\/div>\n<p>Han tenido que pasar m\u00e1s de 90 a\u00f1os para que haya por fin una vacuna de origen humano para la tuberculosis, una de las enfermedades infecciosas<a href=\"http:\/\/www.abc.es\/salud\/noticias\/nueva-vacuna-refuerza-eficacia-tuberculosis-15903.html\"> <\/a>m\u00e1s graves que causa m\u00e1s muertes cada a\u00f1o en el mundo, m\u00e1s de 1,5 millones. El nuevo compuesto, llamado MTBVAC, es un producto desarrollado por la Universidad de Zaragoza y la empresa biofarmac\u00e9utica Biofabri, en colaboraci\u00f3n con la Tuberculosis Vaccine Iniciative y el hospital Universitario de Vaudois, en Suiza, \u00abes la primera vacuna para la tuberculosis elaborada a partir de una cepa del bacilo de la tuberculosis, el mycobacterium tuberculosis, humano lo que la convierte en un &#8216;hito cient\u00edfico&#8217;\u00bb, asegura Carlos Mart\u00edn, responsable del dise\u00f1o del compuesto.<\/p>\n<p>MTBVAC es la primera vacuna viva atenuada del bacilo de la tuberculosis humano que se encuentra en ensayo cl\u00ednico. \u00abDe las 12 vacunas preventivas que se est\u00e1n analizando actualmente es la \u00fanica de origen humano, y es la que ha mostrado una mayor eficacia en estudios en animales\u00bb, destaca Mart\u00edn. Adem\u00e1s, la vacuna trata de activar el sistema inmune para que \u00e9ste sea capaz de reconocer el bacilo de la tuberculosis y proteja a largo plazo la forma m\u00e1s com\u00fan de la enfermedad, la respiratoria. El hecho de que se haya realizado a partir de una cepa del bacilo humano la convierte, subray\u00f3 Mart\u00edn, en \u00ab\u00fanica\u00bb. No hay que olvidar que la actual vacuna, BCG, desarrollada en Instituto Pasteur, en Francia, a principios del siglo XX, es una vacuna de origen bovino.<\/p>\n<p>Aunque de momento la vacuna acaba de concluir un ensayo cl\u00ednico en fase I, en el que se eval\u00faa su seguridad en voluntarios sanos, las expectativas son \u00abmuy favorables\u00bb, afirma Francois Spertini, responsable del ensayo cl\u00ednico desarrollado en el hospital suizo en el que se ha probado la vacuna en 36 voluntarios y cuyos resultados en t\u00e9rminos de seguridad se conocer\u00e1n en un plazo de 7 a 9 meses. Sin embargo, Spertini considera que la vacuna es \u00absegura\u00bb porque a fecha de hoy \u00abno ha inducido la enfermedad en ninguno de los voluntarios\u00bb. Y, a\u00f1ade: \u00abes una de las vacunas m\u00e1s seguras que ha testado en mi carrera aunque, todav\u00eda tenemos que verificar a largo plazo dicha seguridad\u00bb.<\/p>\n<p><b>Carrera de fondo<\/b><\/p>\n<p>Pero a la &#8216;vacuna espa\u00f1ola&#8217; le queda todav\u00eda una carrera de fondo en la que hay dos factores fundamentales: los resultados de seguridad y eficacia y la financiaci\u00f3n. \u00abEn realidad todo depende de los resultados de esta primera fase del ensayo cl\u00ednico en fase I y de la segunda etapa, que se har\u00e1n en reci\u00e9n nacidos, que es la poblaci\u00f3n diana en donde se va a emplear la vacuna\u00bb, explica Mart\u00edn. El problema con las vacunas de la tuberculosis, dice el investigador espa\u00f1ol, es que no existen \u00abmarcadores de eficacia\u00bb, es decir, \u00abno sabemos si la vacuna a conferido protecci\u00f3n frente a la enfermedad o no por lo que nos obliga a hacer lo que se denomina una &#8216;prueba de eficacia&#8217;, que consiste un ensayo cl\u00ednico en miles de personas en pa\u00edses en los que la tuberculosis es end\u00e9mica\u00bb. Pero antes, reconoce, hay que finalizar la segunda fase del ensayo cl\u00ednico para evaluar su seguridad y se ha previsto probar la vacuna en 36 ni\u00f1os sanos. Si la vacuna espa\u00f1ola ratifica su seguridad, se iniciar\u00e1 la denominada &#8216;prueba de eficacia&#8217;, que, seg\u00fan Eugenia Puentes, de Biofabri, se ha previsto realizar en Sud\u00e1frica. La biofarmac\u00e9utica Biofabri ser\u00eda la encargada de fabricar la vacuna para todo el mundo, \u00abalgo que se har\u00e1 en Espa\u00f1a\u00bb, afirm\u00f3 Puentes.<\/p>\n<p><b>Financiaci\u00f3n<\/b><\/p>\n<p>En cuanto a la financiaci\u00f3n, los expertos esperan que si los resultados de seguridad y eficacia son buenos, la investigaci\u00f3n \u00abpuede llegar a costar en total uno 200 millones de euros\u00bb. Por su parte, Puentes ha confirmado que est\u00e1n buscando construir una planta industrial para comercializar la vacuna. \u00abestamos trabajando en la optimizaci\u00f3n del proceso del dise\u00f1o de una planta industrial que permita distribuir la vacuna a nivel mundo la y a un precio asequible, dado que es una vacuna destinada a pa\u00edses en desarrollo\u00bb, afirm\u00f3.<\/p>\n<p>En este escenario m\u00e1s positivo, afirm\u00f3 Jelle Thole, Director General de Tuberculosis Vaccine Iniciative, \u00abpodr\u00edamos estar hablando de 10 a\u00f1os para su comercializaci\u00f3n\u00bb. Tholle subray\u00f3 dos premisas fundamentales con las que se est\u00e1 trabajando: que la vacuna sea universal y que est\u00e9 alalcance de los pa\u00edses en v\u00edas de desarrollo, donde mayor incidencia hay de esta enfermedad. \u00abEse es nuestro compromiso\u00bb.<\/p>\n<div>\n<\/div>\n<div style=\"text-align: right;\">\nFuente:<a href=\"http:\/\/www.abc.es\/salud\/noticias\/investigadores-espanoles-desarrollan-primera-vacuna-16243.html\" target=\"_blank\"> ABC<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Han tenido que pasar m\u00e1s de 90 a\u00f1os para que haya por fin una vacuna de origen humano para la tuberculosis, una de las enfermedades infecciosas m\u00e1s graves que causa m\u00e1s muertes cada a\u00f1o en el mundo, m\u00e1s de 1,5 millones. El nuevo compuesto, llamado MTBVAC, es un producto desarrollado por la Universidad de Zaragoza [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":24506,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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tenido que pasar m\u00e1s de 90 a\u00f1os para que haya por fin una vacuna de origen humano para la tuberculosis, una de las enfermedades infecciosas m\u00e1s graves que causa m\u00e1s muertes cada a\u00f1o en el mundo, m\u00e1s de 1,5 millones. 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