{"id":21254,"date":"2013-09-25T12:44:00","date_gmt":"2013-09-25T10:44:00","guid":{"rendered":"https:\/\/www.opc.cat\/un-arma-eficaz-contra-la-resistencia-a-los-antibioticos-2\/"},"modified":"2013-09-25T12:44:00","modified_gmt":"2013-09-25T10:44:00","slug":"un-arma-eficaz-contra-la-resistencia-a-los-antibioticos-2","status":"publish","type":"post","link":"https:\/\/www.opc.cat\/es\/un-arma-eficaz-contra-la-resistencia-a-los-antibioticos-2\/","title":{"rendered":"Un arma eficaz contra la resistencia a los antibi\u00f3ticos"},"content":{"rendered":"<div class=\"separator\" style=\"clear: both; text-align: center;\">\n<a href=\"http:\/\/3.bp.blogspot.com\/-DlpG-8fEb6M\/UkV-WM3R9kI\/AAAAAAAAAH4\/Vsi21DgseTY\/s1600\/27-antibiotico.jpg\" imageanchor=\"1\" style=\"clear: right; float: right; margin-bottom: 1em; margin-left: 1em;\"><img fetchpriority=\"high\" decoding=\"async\" border=\"0\" height=\"210\" src=\"https:\/\/www.opc.cat\/wp-content\/uploads\/2013\/09\/27-antibiotico.jpg\" width=\"320\" \/><\/a><\/div>\n<p>Los antibi\u00f3ticos fueron uno de los grandes avances de la medicina moderna y, en justa correspondencia, su p\u00e9rdida de eficacia es uno de los grandes problemas de la contempor\u00e1nea. Cuanto m\u00e1s usamos \u2013y abusamos de\u2014 los antibi\u00f3ticos, m\u00e1s resistentes se hacen las bacterias a ellos, hasta el extremo de que buena parte de la mortalidad hospitalaria se debe a agentes infecciosos refractarios a cualquiera de estos f\u00e1rmacos o sus combinaciones. Cient\u00edficos daneses presentan ahora una soluci\u00f3n asombrosamente simple: alternar entre ciertos pares exactos de antibi\u00f3ticos.<\/p>\n<p>No vale alternar cualquier antibi\u00f3tico con cualquier otro, como ya saben muchos que lo han hecho. Por ejemplo, el cloranfenicol puede alternarse con la polimixina B, pero no con la fosfomicina ni con la rifampicina; la tetraciclina puede alternarse con la colistina, la nitrofuranto\u00edna o la estreptomicina, pero no con la kanamicina o la amoxicilina. Cada par de antibi\u00f3ticos \u00fatil para combatir la resistencia es un mundo, y no pod\u00eda predecirse a partir de primeros principios. Ahora, hay que usar la lista de los bi\u00f3logos daneses.<\/p>\n<p>Cambiar al paciente de un antibi\u00f3tico a otro es una pr\u00e1ctica obvia y extendida cuando surgen resistencias \u2013aunque no siempre eficaz\u2014, pero el trabajo de hoy va mucho m\u00e1s all\u00e1, al identificar las secuencias de f\u00e1rmacos exactas que permiten erradicar la resistencia y al desarrollar un sistema racional. Lejla Imamovic y Morten Sommer, del departamento de biolog\u00eda de sistemas de la Universidad T\u00e9cnica de Dinamarca, en Lyngby, presentan hoy en Science Translational Medicine, \u2014la subsidiaria de la revista Science dedicada a investigaciones de evidente o inmediata utilidad m\u00e9dica\u2014 una lista de los pares de antibi\u00f3ticos cuya alternancia evita la aparici\u00f3n de resistencias en las bacterias.<\/p>\n<p>Los autores reconocen que sus resultados no pueden llegar a la pr\u00e1ctica cl\u00ednica sin superar antes los ensayos cl\u00ednicos que demuestren su seguridad y eficacia. Sus experimentos se han llevado a cabo in vitro,con una bacteria modelo de laboratorio \u2013Escherichia coli, un habitante tradicional del intestino humano\u2014 y t\u00e9cnicas de evoluci\u00f3n artificial para hacerla resistente a cada uno de los 23 antibi\u00f3ticos m\u00e1s utilizados en la pr\u00e1ctica m\u00e9dica.<\/p>\n<p>Tambi\u00e9n han confirmado sus resultados con dos cepas bacterianas aisladas de pacientes, ambas recogidas en los hospitales daneses por constituir casos notables de multirresistencia, o resistencia simult\u00e1nea, a media docena de los antibi\u00f3ticos m\u00e1s valiosos. Y sus conclusiones se mantienen con ese material m\u00e1s realista: utilizar los pares de antibi\u00f3ticos correctos suprime la resistencia. \u00bfHay posibilidades, entonces, de abordar los ensayos cl\u00ednicos a corto plazo?<\/p>\n<p>\u201cS\u00ed\u201d, responde Sommer a EL PA\u00cdS, \u201ccreemos que este concepto, el ciclo de sensibilidad colateral, ser\u00e1 directamente aplicable para el tratamiento de pacientes, puesto que los antibi\u00f3ticos que hemos usado en nuestro estudio ya est\u00e1n aprobados por los reguladores sanitarios; obviamente, estos ensayos requieren que el m\u00e9dico eval\u00fae su validez cl\u00ednica; en el caso de las infecciones cr\u00f3nicas, pensamos que los ciclos de sensibilidad colateral tienen un fuerte potencial de impactar en la pr\u00e1ctica cl\u00ednica\u201d.<\/p>\n<p>La \u201csensibilidad colateral\u201d a la que se refiere Sommer es el concepto central de su investigaci\u00f3n y se trata de lo siguiente. Cuando una poblaci\u00f3n de bacterias se ve atacada por un antibi\u00f3tico, lo habitual es que intente adaptarse a \u00e9l. Este proceso, aparentemente dotado de un prop\u00f3sito presciente, se basa en realidad en la m\u00e1s ciega l\u00f3gica darwiniana: las meras variantes aleatorias que, por casualidad, resultan vivir un poco mejor en el nuevo ambiente t\u00f3xico causado por el f\u00e1rmaco sobreviven y se reproducen m\u00e1s que el resto; la repetici\u00f3n de este proceso durante muchas generaciones \u2013y una generaci\u00f3n de bacterias puede durar tan poco como 20 minutos\u2014 acaban generando una poblaci\u00f3n de bacterias resistentes al antibi\u00f3tico en cuesti\u00f3n.<\/p>\n<p>El descubrimiento de Imamovic y Sommer es que ese proceso de adaptaci\u00f3n para resistir a un antibi\u00f3tico genera siempre una hipersensibilidad a otro antibi\u00f3tico. No a cualquier otro, sino a un antibi\u00f3tico concreto de una lista de 23, o a lo sumo a unos pocos de esa lista. La explicaci\u00f3n es bien curiosa: que la adaptaci\u00f3n a los antibi\u00f3ticos se basa en el ajuste fino de una red de genes interrelacionados: una red gen\u00e9tica que, literalmente, se ocupa de bregar con los desaf\u00edos qu\u00edmicos del entorno. Y al tocar la red para resistir a un antibi\u00f3tico, a la bacteria le resulta inevitable hacerse muy vulnerable a otro.<\/p>\n<p>En la l\u00f3gica profunda de las redes metab\u00f3licas y de los circuitos gen\u00e9ticos que las codifican \u2013o las significan\u2014 yace una balanza que imparte una suerte de justicia bioqu\u00edmica. Siempre es posible adaptarse a una agresi\u00f3n, pero nunca sale gratis.<\/p>\n<p>Las resistencias a los antibi\u00f3ticos llevan d\u00e9cadas creciendo en los entornos hospitalarios, y cada vez m\u00e1s en cualquier otro entorno. La raz\u00f3n es el uso extensivo \u2014en el caso de los hospitales\u2014 o directamente el abuso \u2013en el de la recetitis con que se viene tratando la soledad en estos tiempos duros\u2014 de estos f\u00e1rmacos esenciales, que junto al saneamiento de las aguas se han podido apuntar el grueso de la duplicaci\u00f3n de la esperanza de vida que han conseguido las sociedades occidentales en el siglo XX. Y de la que esperan alcanzar los pa\u00edses en desarrollo en el XXI, y mejor antes que despu\u00e9s.<\/p>\n<p>El trabajo de los cient\u00edficos daneses se centra en los antibi\u00f3ticos, pero la aparici\u00f3n de resistencias no es ni mucho menos una peculiaridad de estos f\u00e1rmacos: lo mismo ocurre con los tratamientos para la tuberculosis, los paliativos de la malaria o la quimioterapia contra el c\u00e1ncer. Sommer cree que su estrategia de ciclos de \u201csensibilidad colateral\u201d puede tener relevancia tambi\u00e9n en esos campos alejados de su experimentaci\u00f3n.<\/p>\n<p>\u201cEn el caso del c\u00e1ncer\u201d, sigue diciendo a este diario, \u201cse sabe tambi\u00e9n que el desarrollo de resistencia a la quimioterapia en el tumor puede resultar en sensibilidad colateral (hipersensibilidad a un f\u00e1rmaco distinto); de acuerdo con esto, tambi\u00e9n vemos un potencial notable para aplicar los ciclos de sensibilidad colateral a los tratamientos del c\u00e1ncer\u201d.<\/p>\n<p>En la variedad no solo est\u00e1 el gusto: tambi\u00e9n la vida.<\/p>\n<div style=\"text-align: right;\">\n<i>Fuente: <a href=\"http:\/\/sociedad.elpais.com\/sociedad\/2013\/09\/25\/actualidad\/1380132083_130512.html\" target=\"_blank\">El Pa\u00eds<\/a><\/i><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Los antibi\u00f3ticos fueron uno de los grandes avances de la medicina moderna y, en justa correspondencia, su p\u00e9rdida de eficacia es uno de los grandes problemas de la contempor\u00e1nea. Cuanto m\u00e1s usamos \u2013y abusamos de\u2014 los antibi\u00f3ticos, m\u00e1s resistentes se hacen las bacterias a ellos, hasta el extremo de que buena parte de la mortalidad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":24563,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[3200,3203],"tags":[3560],"class_list":["post-21254","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biocienciaysalud","category-congresos-profesionales-es","tag-antibioticos-es"],"spectra_custom_meta":{"_encloseme":["1"],"_thumbnail_id":["24563"],"_uag_page_assets":["a:9:{s:3:\"css\";s:42753:\".uagb-ifb-content>svg *{-webkit-transition:all 0.2s;-o-transition:all 0.2s;transition:all 0.2s}.uagb-ifb-content>svg,.uagb-ifb-content{display:inline-block}.uagb-ifb-content>svg{vertical-align:middle;width:inherit;height:inherit;font-style:initial}.uagb-ifb-content .uagb-ifb-icon-wrap svg{box-sizing:content-box;width:inherit;height:inherit}.uagb-ifb-button-wrapper:empty{display:none}div.uagb-ifb-button-wrapper a.uagb-infobox-cta-link,div.uagb-ifb-cta a.uagb-infobox-cta-link,.entry .entry-content a.uagb-infobox-cta-link,a.uagb-infobox-link-wrap,.entry .entry-content a.uagb-infobox-link-wrap{text-decoration:none;align-items:center}.uagb-infobox-icon-left-title.uagb-infobox-image-valign-middle .uagb-ifb-title-wrap,.uagb-infobox-icon-right-title.uagb-infobox-image-valign-middle .uagb-ifb-title-wrap,.uagb-infobox-image-valign-middle .uagb-ifb-icon-wrap,.uagb-infobox-image-valign-middle .uagb-ifb-image-content,.uagb-infobox-icon-left.uagb-infobox-image-valign-middle .uagb-ifb-content,.uagb-infobox-icon-right.uagb-infobox-image-valign-middle .uagb-ifb-content{-ms-flex-item-align:center;-webkit-align-self:center;align-self:center}.uagb-infobox-icon-left-title.uagb-infobox-image-valign-top .uagb-ifb-title-wrap,.uagb-infobox-icon-right-title.uagb-infobox-image-valign-top .uagb-ifb-title-wrap,.uagb-infobox-image-valign-top .uagb-ifb-icon-wrap,.uagb-infobox-image-valign-top .uagb-ifb-image-content,.uagb-infobox-icon-left.uagb-infobox-image-valign-top .uagb-ifb-content,.uagb-infobox-icon-right.uagb-infobox-image-valign-top .uagb-ifb-content{-webkit-align-self:self-start;align-self:self-start}.uagb-infobox-left{justify-content:flex-start;text-align:left;-webkit-box-pack:start;-ms-flex-pack:start;-webkit-justify-content:flex-start;-moz-box-pack:start}.uagb-infobox-center{justify-content:center;text-align:center;-webkit-box-pack:center;-ms-flex-pack:center;-webkit-justify-content:center;-moz-box-pack:center}.uagb-infobox-right{justify-content:flex-end;text-align:right;-webkit-box-pack:end;-ms-flex-pack:end;-webkit-justify-content:flex-end;-moz-box-pack:end}.uagb-infobox-icon-above-title.uagb-infobox__content-wrap,.uagb-infobox-icon-below-title.uagb-infobox__content-wrap{display:block;width:100%}.uagb-infobox-icon-left-title .uagb-ifb-content>svg,.uagb-infobox-icon-left .uagb-ifb-content>svg{margin-right:10px}.uagb-infobox-icon-right-title .uagb-ifb-content>svg,.uagb-infobox-icon-right .uagb-ifb-content>svg{margin-left:10px}.uagb-infobox-icon-left.uagb-infobox__content-wrap,.uagb-infobox-icon-right.uagb-infobox__content-wrap,.uagb-infobox-icon-left-title .uagb-ifb-left-title-image,.uagb-infobox-icon-right-title .uagb-ifb-right-title-image{display:-webkit-box;display:-ms-flexbox;display:-webkit-flex;display:-moz-box;display:flex;-js-display:flex}.uagb-infobox-icon-left-title .uagb-ifb-left-title-image .uagb-ifb-image-content,.uagb-infobox-icon-right-title .uagb-ifb-right-title-image .uagb-ifb-image-content,.uagb-infobox-icon-left .uagb-ifb-image-content,.uagb-infobox-icon-right .uagb-ifb-image-content{flex-shrink:0;line-height:0}.uagb-infobox-icon-left-title .uagb-ifb-left-title-image .uagb-ifb-title-wrap,.uagb-infobox-icon-right-title .uagb-ifb-right-title-image .uagb-ifb-title-wrap,.uagb-infobox-icon-left .uagb-ifb-content,.uagb-infobox-icon-right .uagb-ifb-content{flex-grow:1}.uagb-infobox-icon-right.uagb-infobox__content-wrap,.uagb-infobox-icon-right-title .uagb-ifb-right-title-image{-webkit-box-pack:end;-ms-flex-pack:end;-webkit-justify-content:flex-end;-moz-box-pack:end;justify-content:flex-end}.uagb-ifb-content img{position:relative;display:inline-block;line-height:0;width:auto;height:auto !important;max-width:100%;border-radius:inherit;-webkit-box-sizing:content-box;-moz-box-sizing:content-box;-webkit-border-radius:inherit}.uagb-infobox-module-link{position:absolute;top:0;right:0;bottom:0;left:0;z-index:4;width:100%;height:100%}.uagb-edit-mode .uagb-infobox-module-link{z-index:2}.uagb-infobox-link-icon-after{margin-right:0;margin-left:5px}.uagb-infobox-link-icon-before{margin-right:5px;margin-left:0}.uagb-infobox-link-icon{-webkit-transition:all 200ms linear;transition:all 200ms linear}.uagb-infobox__content-wrap{box-sizing:border-box;position:relative;width:100%;word-break:break-word;z-index:1}.uagb-ifb-separator{display:inline-block;margin:0;border-top-color:#333;border-top-style:solid;border-top-width:2px;line-height:0}.uagb-ifb-button-wrapper{line-height:1}.uagb-ifb-button-wrapper.uagb-ifb-button-type-text .uagb-infobox-cta-link.wp-block-button__link{background-color:unset;border:none}.uagb-ifb-button-wrapper.uagb-ifb-button-type-text .uagb-infobox-cta-link.wp-block-button__link:hover{background-color:unset;border-color:unset}.uagb-ifb-button-wrapper .uagb-infobox-cta-link{cursor:pointer}.uagb-ifb-button-wrapper .uagb-infobox-cta-link.wp-block-button__link{width:auto}.uagb-ifb-button-wrapper .wp-block-button__link svg,.uagb-ifb-button-wrapper .ast-outline-button svg{fill:currentColor}.uagb-infobox__content-wrap a{-webkit-box-shadow:none;box-shadow:none;text-decoration:none}.uagb-ifb-title-wrap{width:100%}.uagb-ifb-title{margin-block-start:0}.uagb-ifb-title-wrap .uagb-ifb-title-prefix{display:block;padding:0;margin:0}.uagb-infobox__content-wrap.uagb-infobox__content-wrap{position:relative}.uagb-ifb-content{width:100%}.uagb-infobox__content-wrap.uagb-infobox,.uagb-ifb-content,.uagb-ifb-title-wrap,.uagb-ifb-title-prefix *,svg.dashicon.dashicons-upload{z-index:1}a.uagb-infobox-link-wrap{color:inherit}.uagb-ifb-content p:empty{display:none}.uagb-infobox__content-wrap .uagb-ifb-content img{display:inline-block;max-width:100%}.uagb-infobox__content-wrap .uagb-ifb-content svg{display:inline-block}.uagb-infobox__content-wrap .uagb-ifb-icon-wrap,.uagb-infobox-icon-left .uagb-ifb-image-content,.uagb-infobox-icon-right .uagb-ifb-image-content{box-sizing:content-box}.uagb-infobox-cta-link>svg{vertical-align:middle;width:15px;height:15px;font-size:15px}.uagb-infobox-cta-link{display:inline-flex}.block-editor-page #wpwrap .uagb-infobox-cta-link svg,.uagb-infobox-cta-link svg{font-style:normal}.uagb-infobox-icon-left-title .uagb-ifb-icon-wrap,.uagb-infobox-icon-left .uagb-ifb-icon-wrap{margin-right:10px;line-height:0}.uagb-infobox-icon-right-title .uagb-ifb-icon-wrap,.uagb-infobox-icon-right .uagb-ifb-icon-wrap{margin-left:10px;line-height:0}html[dir=\"rtl\"] .uagb-infobox-icon-left-title .uagb-ifb-icon-wrap,html[dir=\"rtl\"] .uagb-infobox-icon-left .uagb-ifb-icon-wrap{margin-left:10px;line-height:0}html[dir=\"rtl\"] .uagb-infobox-icon-right-title .uagb-ifb-icon-wrap,html[dir=\"rtl\"] .uagb-infobox-icon-right .uagb-ifb-icon-wrap{margin-right:10px;line-height:0}html[dir=\"rtl\"] .uagb-infobox-left{justify-content:flex-end;text-align:right;-webkit-box-pack:end;-ms-flex-pack:end;-webkit-justify-content:flex-end;-moz-box-pack:end}html[dir=\"rtl\"] .uagb-infobox-right{justify-content:flex-start;text-align:left;-webkit-box-pack:start;-ms-flex-pack:start;-webkit-justify-content:flex-start;-moz-box-pack:start}.uagb-infobox-icon-left .uagb-ifb-left-right-wrap,.uagb-infobox-icon-right .uagb-ifb-left-right-wrap,.uagb-infobox-icon-left-title .uagb-ifb-left-title-image,.uagb-infobox-icon-right-title .uagb-ifb-right-title-image{display:-webkit-box;display:-ms-flexbox;display:flex}.uagb-infobox-icon-right .uagb-ifb-left-right-wrap,.uagb-infobox-icon-right-title .uagb-ifb-right-title-image{-webkit-box-pack:end;-ms-flex-pack:end;-webkit-justify-content:flex-end;-moz-box-pack:end;justify-content:flex-end}a.uagb-infbox__link-to-all{position:absolute;top:0;left:0;z-index:3;width:100%;height:100%;box-shadow:none;text-decoration:none;-webkit-box-shadow:none}@media only screen and (max-width: 976px){.uagb-infobox-stacked-tablet.uagb-infobox__content-wrap .uagb-ifb-image-content{padding:0;margin-bottom:20px}.uagb-infobox-stacked-tablet.uagb-reverse-order-tablet.uagb-infobox__content-wrap{display:-webkit-inline-box;display:-ms-inline-flexbox;display:-webkit-inline-flex;display:-moz-inline-box;display:inline-flex;flex-direction:column-reverse;-js-display:inline-flex;-webkit-box-orient:vertical;-webkit-box-direction:reverse;-ms-flex-direction:column-reverse;-webkit-flex-direction:column-reverse;-moz-box-orient:vertical;-moz-box-direction:reverse}.uagb-infobox-stacked-tablet.uagb-infobox__content-wrap .uagb-ifb-content,.uagb-infobox-stacked-tablet.uagb-infobox__content-wrap .uagb-ifb-icon-wrap,.uagb-infobox-stacked-tablet.uagb-infobox__content-wrap .uagb-ifb-image-content{display:block;width:100%;text-align:center}.uagb-infobox-stacked-tablet.uagb-infobox__content-wrap .uagb-ifb-icon-wrap,.uagb-infobox-stacked-tablet.uagb-infobox__content-wrap .uagb-ifb-image-content{margin-right:0;margin-left:0}.uagb-infobox-stacked-tablet.uagb-infobox__content-wrap{display:inline-block}.uagb-infobox-icon-left-title.uagb-infobox-stacked-tablet .uagb-ifb-image-content,.uagb-infobox-icon-left-title.uagb-infobox-stacked-tablet .uagb-ifb-icon-wrap,.uagb-infobox-icon-left.uagb-infobox-stacked-tablet .uagb-ifb-image-content,.uagb-infobox-icon-left.uagb-infobox-stacked-tablet .uagb-ifb-icon-wrap{margin-right:0}.uagb-infobox-icon-right-title.uagb-infobox-stacked-tablet .uagb-ifb-image-content,.uagb-infobox-icon-right-title.uagb-infobox-stacked-tablet .uagb-ifb-icon-wrap,.uagb-infobox-icon-right.uagb-infobox-stacked-tablet .uagb-ifb-image-content,.uagb-infobox-icon-right.uagb-infobox-stacked-tablet .uagb-ifb-icon-wrap{margin-left:0}.uagb-infobox-icon-left-title .uagb-ifb-separator{margin:10px 0}}@media screen and (max-width: 767px){.uagb-infobox-stacked-mobile.uagb-infobox__content-wrap{display:inline-block}.uagb-infobox-stacked-mobile.uagb-infobox__content-wrap .uagb-ifb-image-content,.uagb-infobox-stacked-mobile.uagb-infobox__content-wrap .uagb-ifb-icon-wrap{padding:0;margin-bottom:20px;margin-right:0;margin-left:0}.uagb-infobox-stacked-mobile.uagb-infobox__content-wrap.uagb-reverse-order-mobile{display:-webkit-inline-box;display:-ms-inline-flexbox;display:-webkit-inline-flex;display:-moz-inline-box;display:inline-flex;flex-direction:column-reverse;-js-display:inline-flex;-webkit-box-orient:vertical;-webkit-box-direction:reverse;-ms-flex-direction:column-reverse;-webkit-flex-direction:column-reverse;-moz-box-orient:vertical;-moz-box-direction:reverse}.uagb-infobox-stacked-mobile.uagb-infobox__content-wrap .uagb-ifb-image-content,.uagb-infobox-stacked-mobile.uagb-infobox__content-wrap .uagb-ifb-icon-wrap,.uagb-infobox-stacked-mobile.uagb-infobox__content-wrap .uagb-ifb-content{display:block;width:100%;text-align:center}.uagb-infobox-icon-left-title.uagb-infobox-stacked-mobile .uagb-ifb-image-content,.uagb-infobox-icon-left-title.uagb-infobox-stacked-mobile .uagb-ifb-icon-wrap,.uagb-infobox-icon-left.uagb-infobox-stacked-mobile .uagb-ifb-image-content,.uagb-infobox-icon-left.uagb-infobox-stacked-mobile .uagb-ifb-icon-wrap{margin-right:0}.uagb-infobox-icon-right-title.uagb-infobox-stacked-mobile .uagb-ifb-image-content,.uagb-infobox-icon-right-title.uagb-infobox-stacked-mobile .uagb-ifb-icon-wrap,.uagb-infobox-icon-right.uagb-infobox-stacked-mobile .uagb-ifb-image-content,.uagb-infobox-icon-right.uagb-infobox-stacked-mobile .uagb-ifb-icon-wrap{margin-left:0}.uagb-infobox-icon-left-title .uagb-ifb-separator{margin:10px 0}}.uagb-ifb-icon svg{width:inherit;height:inherit;vertical-align:middle}.uagb-ifb-button-icon{height:15px;width:15px;font-size:15px;vertical-align:middle}.uagb-ifb-button-icon svg{height:inherit;width:inherit;display:inline-block}.uagb-ifb-button-icon.uagb-ifb-align-icon-after{float:right}.uagb-ifb-cta-button{display:inline-block}.uagb-disable-link{pointer-events:none}@media only screen and (min-width: 977px){.uagb-infobox-margin-wrapper{display:flex}}.uagb-ifb-content .uagb-ifb-desc p:last-child{margin-bottom:0}\n.uagb-block-3ee00f6a .uagb-ifb-icon{width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-ifb-icon > span{font-size: 30px;width: 30px;line-height: 30px;color: #333;}.uagb-block-3ee00f6a .uagb-ifb-icon svg{fill: #333;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap svg{width: 30px;height: 30px;line-height: 30px;font-size: 30px;color: #333;fill: #333;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-icon-wrap svg{line-height: 30px;font-size: 30px;color: #333;fill: #333;}.uagb-block-3ee00f6a .uagb-iconbox-icon-wrap{margin: auto;display: inline-flex;align-items: center;justify-content: center;box-sizing: content-box;width: 30px;height: 30px;line-height: 30px;padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap > svg{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-icon-wrap > svg{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-left-title-image svg{width: 30px;line-height: 30px;font-size: 30px;color: #333;fill: #333;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-right-title-image svg{width: 30px;line-height: 30px;font-size: 30px;color: #333;fill: #333;}.uagb-block-3ee00f6a .uagb-infobox__content-wrap .uagb-ifb-imgicon-wrap{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;}.uagb-block-3ee00f6a .uagb-infobox .uagb-ifb-image-content img{border-radius: 0px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap img{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;border-radius: 0px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-right-title-image > img{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;border-radius: 0px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-left-title-image > img{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;border-radius: 0px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content > img{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;border-radius: 0px;}.uagb-block-3ee00f6a .uagb-ifb-title-wrap .uagb-ifb-title-prefix{margin-bottom: 10px;margin-top: 5px;}.uagb-block-3ee00f6a.wp-block-uagb-info-box .uagb-ifb-title{margin-bottom: 10px;}.uagb-block-3ee00f6a.wp-block-uagb-info-box .uagb-ifb-desc{margin-bottom: 5px;margin-top: 0px;margin-left: 0px;margin-right: 0px;}.uagb-block-3ee00f6a .uagb-ifb-separator{width: 30%;border-top-width: 2px;border-top-color: #333;border-top-style: solid;margin-bottom: 0px;}.uagb-block-3ee00f6a .uagb-infobox__content-wrap .uagb-ifb-separator{width: 30%;border-top-width: 2px;border-top-color: #333;border-top-style: solid;}.uagb-block-3ee00f6a .uagb-ifb-align-icon-after{margin-left: 5px;}.uagb-block-3ee00f6a .uagb-ifb-align-icon-before{margin-right: 5px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content svg{box-sizing: content-box;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content img{box-sizing: content-box;}.uagb-block-3ee00f6a .uagb-infobox__content-wrap{text-align: left;}.uagb-block-3ee00f6a.uagb-infobox-icon-above-title{text-align: left;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg {margin-left: 5px;}[dir=rtl] .uagb-block-3ee00f6a .uagb-iconbox-icon-wrap{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap > svg{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-icon-wrap > svg{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap img{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-right-title-image > img{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-left-title-image > img{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content > img{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap{text-align: right;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox-icon-above-title{text-align: right;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg{margin-right: 5px;margin-left: 0px;}@media only screen and (max-width: 976px) {.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap > svg{width: 30px;height: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-icon-wrap > svg{line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content img{box-sizing: content-box;}.uagb-block-3ee00f6a .uagb-ifb-icon{width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-ifb-icon > span{font-size: 30px;width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-iconbox-icon-wrap{width: 30px;height: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-left-title-image > svg{width: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-right-title-image > svg{width: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg {margin-left: 5px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg{margin-right: 5px;margin-left: 0px;}}@media only screen and (max-width: 767px) {.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap > svg{width: 30px;height: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-icon-wrap > svg{line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-left-title-image > svg{width: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-right-title-image > svg{width: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content img{box-sizing: content-box;}.uagb-block-3ee00f6a .uagb-ifb-icon{width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-ifb-icon > span{font-size: 30px;width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-iconbox-icon-wrap{width: 30px;height: 30px;line-height: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg {margin-left: 5px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg{margin-right: 5px;margin-left: 0px;}}.uag-blocks-common-selector{z-index:var(--z-index-desktop) !important}@media (max-width: 976px){.uag-blocks-common-selector{z-index:var(--z-index-tablet) !important}}@media (max-width: 767px){.uag-blocks-common-selector{z-index:var(--z-index-mobile) !important}}\n.wp-block-uagb-separator{text-align:center;box-sizing:border-box;line-height:0}.wp-block-uagb-separator__inner{display:inline-block}.wp-block-uagb-separator:not(.wp-block-uagb-separator--text):not(.wp-block-uagb-separator--icon) .wp-block-uagb-separator__inner{border-top-style:solid;-webkit-mask:var(--my-background-image);-webkit-mask-size:38px 100%;-webkit-mask-repeat:repeat-x}.wp-block-uagb-separator--text .wp-block-uagb-separator__inner,.wp-block-uagb-separator--icon .wp-block-uagb-separator__inner{display:flex;justify-content:center;align-items:center;margin:0 auto}.wp-block-uagb-separator--text .wp-block-uagb-separator__inner::before,.wp-block-uagb-separator--icon .wp-block-uagb-separator__inner::before{display:block;content:\"\";border-bottom:0;flex-grow:1;border-top-color:#333;border-top-style:solid;-webkit-mask:var(--my-background-image);-webkit-mask-size:38px 100%;-webkit-mask-repeat:repeat-x}.wp-block-uagb-separator--text .wp-block-uagb-separator__inner::after,.wp-block-uagb-separator--icon .wp-block-uagb-separator__inner::after{display:block;content:\"\";border-bottom:0;flex-grow:1;border-top-color:#333;border-top-style:solid;-webkit-mask:var(--my-background-image);-webkit-mask-size:38px 100%;-webkit-mask-repeat:repeat-x}.wp-block-uagb-separator--icon .wp-block-uagb-separator-element svg{font-size:30px;color:#333;fill:#333;width:30px;height:30px;line-height:30px;max-width:none}.wp-block-uagb-separator--text .wp-block-uagb-separator-element .uagb-html-tag{word-break:initial;margin:0}\n.uagb-block-474a455e.wp-block-uagb-separator{text-align: center;}.uagb-block-474a455e.wp-block-uagb-separator--text .wp-block-uagb-separator-element .uagb-html-tag{font-style: normal;line-height: 1em;}.uagb-block-474a455e.wp-block-uagb-separator:not(.wp-block-uagb-separator--text):not(.wp-block-uagb-separator--icon) .wp-block-uagb-separator__inner{-webkit-mask-size: 5px 100%;border-top-width: 3px;width: 100%;border-top-color: #eeeeee;border-top-style: solid;margin-top: 5px;margin-bottom: 5px;}@media only screen and (max-width: 976px) {.uagb-block-474a455e.wp-block-uagb-separator{text-align: center;}.uagb-block-474a455e.wp-block-uagb-separator--text .wp-block-uagb-separator-element .uagb-html-tag{font-style: normal;margin-bottom: initial;line-height: 1em;}.uagb-block-474a455e.wp-block-uagb-separator:not(.wp-block-uagb-separator--text):not(.wp-block-uagb-separator--icon) .wp-block-uagb-separator__inner{-webkit-mask-size: 5px 100%;width: 100%;border-top-color: #eeeeee;border-top-style: solid;margin-top: 5px;margin-bottom: 5px;}}@media only screen and (max-width: 767px) {.uagb-block-474a455e.wp-block-uagb-separator{text-align: center;}.uagb-block-474a455e.wp-block-uagb-separator--text .wp-block-uagb-separator-element .uagb-html-tag{font-style: normal;margin-bottom: initial;line-height: 1em;}.uagb-block-474a455e.wp-block-uagb-separator:not(.wp-block-uagb-separator--text):not(.wp-block-uagb-separator--icon) .wp-block-uagb-separator__inner{-webkit-mask-size: 5px 100%;width: 100%;border-top-color: #eeeeee;border-top-style: solid;margin-top: 5px;margin-bottom: 5px;}}.uagb-block-474a455e.wp-block-uagb-separator{text-align: center;}.uagb-block-474a455e.wp-block-uagb-separator--text .wp-block-uagb-separator-element .uagb-html-tag{font-style: normal;line-height: 1em;}.uagb-block-474a455e .uagb-separator-spacing-wrapper{margin-top: 0px;margin-right: 0px;margin-bottom: 0px;margin-left: 0px;padding-top: 0px;padding-right: 0px;padding-bottom: 0px;padding-left: 0px;}.uagb-block-474a455e.wp-block-uagb-separator:not(.wp-block-uagb-separator--text):not(.wp-block-uagb-separator--icon) .wp-block-uagb-separator__inner{-webkit-mask-size: 5px 100%;border-top-width: 3px;width: 100%;border-top-color: #eeeeee;border-top-style: solid;margin-top: 5px;margin-bottom: 5px;}@media only screen and (max-width: 976px) {.uagb-block-474a455e.wp-block-uagb-separator{text-align: center;}.uagb-block-474a455e.wp-block-uagb-separator--text .wp-block-uagb-separator-element .uagb-html-tag{font-style: normal;margin-bottom: initial;line-height: 1em;}.uagb-block-474a455e.wp-block-uagb-separator:not(.wp-block-uagb-separator--text):not(.wp-block-uagb-separator--icon) .wp-block-uagb-separator__inner{-webkit-mask-size: 5px 100%;width: 100%;border-top-color: #eeeeee;border-top-style: solid;margin-top: 5px;margin-bottom: 5px;}}@media only screen and (max-width: 767px) {.uagb-block-474a455e.wp-block-uagb-separator{text-align: center;}.uagb-block-474a455e.wp-block-uagb-separator--text .wp-block-uagb-separator-element .uagb-html-tag{font-style: normal;margin-bottom: initial;line-height: 1em;}.uagb-block-474a455e.wp-block-uagb-separator:not(.wp-block-uagb-separator--text):not(.wp-block-uagb-separator--icon) .wp-block-uagb-separator__inner{-webkit-mask-size: 5px 100%;width: 100%;border-top-color: #eeeeee;border-top-style: solid;margin-top: 5px;margin-bottom: 5px;}}.uagb-block-474a455e.wp-block-uagb-separator{text-align: center;}.uagb-block-474a455e.wp-block-uagb-separator--text .wp-block-uagb-separator-element .uagb-html-tag{font-style: normal;line-height: 1em;}.uagb-block-474a455e.wp-block-uagb-separator:not(.wp-block-uagb-separator--text):not(.wp-block-uagb-separator--icon) .wp-block-uagb-separator__inner{-webkit-mask-size: 5px 100%;border-top-width: 3px;width: 100%;border-top-color: #eeeeee;border-top-style: solid;margin-top: 5px;margin-bottom: 5px;}@media only screen and (max-width: 976px) {.uagb-block-474a455e.wp-block-uagb-separator{text-align: center;}.uagb-block-474a455e.wp-block-uagb-separator--text .wp-block-uagb-separator-element .uagb-html-tag{font-style: normal;margin-bottom: initial;line-height: 1em;}.uagb-block-474a455e.wp-block-uagb-separator:not(.wp-block-uagb-separator--text):not(.wp-block-uagb-separator--icon) .wp-block-uagb-separator__inner{-webkit-mask-size: 5px 100%;width: 100%;border-top-color: #eeeeee;border-top-style: solid;margin-top: 5px;margin-bottom: 5px;}}@media only screen and (max-width: 767px) {.uagb-block-474a455e.wp-block-uagb-separator{text-align: center;}.uagb-block-474a455e.wp-block-uagb-separator--text .wp-block-uagb-separator-element .uagb-html-tag{font-style: normal;margin-bottom: initial;line-height: 1em;}.uagb-block-474a455e.wp-block-uagb-separator:not(.wp-block-uagb-separator--text):not(.wp-block-uagb-separator--icon) .wp-block-uagb-separator__inner{-webkit-mask-size: 5px 100%;width: 100%;border-top-color: #eeeeee;border-top-style: solid;margin-top: 5px;margin-bottom: 5px;}}.uagb-tax-not-available{padding:10px;border:1px solid;text-align:center}.uagb-layout-list .uagb-list-wrap{margin-left:10px}.uagb-taxonomy__outer-wrap{margin-bottom:20px}ul.uagb-taxonomy-list-children{margin-bottom:0}.uagb-tax-link h1,.uagb-tax-link h2,.uagb-tax-link h3,.uagb-tax-link h4,.uagb-tax-link h5,.uagb-tax-link h6{margin-top:unset}\n.uagb-block-24ed2987.uagb-taxonomy__outer-wrap.uagb-layout-grid{display: grid;grid-template-columns: repeat(2, 1fr);grid-column-gap: 20px;grid-row-gap: 20px;}.uagb-block-24ed2987.uagb-layout-grid .uagb-taxomony-box{padding-left: 10px;padding-right: 10px;padding-top: 10px;padding-bottom: 10px;grid-column-gap: 20px;background-color: #f5f5f5;text-align: left;box-shadow: 0px 0px   #00000070 ;}.uagb-block-24ed2987.uagb-layout-grid .uagb-tax-title{font-weight: 500;font-size: 18px;line-height: 1.2em;letter-spacing: 0px;color: #3b3b3b;margin-bottom: 5px;}.uagb-block-24ed2987.uagb-layout-grid .uagb-tax-link{color: #777777;}.uagb-block-24ed2987.uagb-layout-list .uagb-tax-list{list-style: disc;color: #3b3b3b;}.uagb-block-24ed2987.uagb-layout-list .uagb-tax-list:hover{color: #3b3b3b;}.uagb-block-24ed2987.uagb-layout-list .uagb-tax-link-wrap:hover{color: #3b3b3b;}.uagb-block-24ed2987.uagb-layout-list .uagb-tax-list a.uagb-tax-link{color: #3b3b3b;}.uagb-block-24ed2987.uagb-layout-list .uagb-tax-list a.uagb-tax-link:hover{color: #3b3b3b;}.uagb-block-24ed2987.uagb-layout-list .uagb-tax-list .uagb-tax-link-wrap{margin-bottom: 10px;}.uagb-block-24ed2987 .uagb-taxonomy-wrap.uagb-layout-grid{display: grid;grid-template-columns: repeat(2, 1fr);grid-column-gap: 20px;grid-row-gap: 20px;}.uagb-block-24ed2987 .uagb-layout-grid .uagb-taxomony-box{padding-left: 10px;padding-right: 10px;padding-top: 10px;padding-bottom: 10px;grid-column-gap: 20px;background-color: #f5f5f5;text-align: left;box-shadow: 0px 0px   #00000070 ;}.uagb-block-24ed2987 .uagb-layout-grid .uagb-tax-title{font-weight: 500;font-size: 18px;line-height: 1.2em;letter-spacing: 0px;color: #3b3b3b;margin-bottom: 5px;}.uagb-block-24ed2987 .uagb-layout-grid .uagb-tax-link{color: #777777;}.uagb-block-24ed2987 .uagb-layout-list .uagb-tax-list{list-style: disc;color: #3b3b3b;}.uagb-block-24ed2987 .uagb-layout-list .uagb-tax-list:hover{color: #3b3b3b;}.uagb-block-24ed2987 .uagb-layout-list .uagb-tax-list a.uagb-tax-link{color: #3b3b3b;}.uagb-block-24ed2987 .uagb-layout-list .uagb-tax-list a.uagb-tax-link:hover{color: #3b3b3b;}.uagb-block-24ed2987 .uagb-layout-list .uagb-tax-list .uagb-tax-link-wrap{margin-bottom: 10px;}.uagb-block-24ed2987.uagb-layout-list .uagb-tax-separator:hover{border-top-color: #b2b4b5;}.uagb-block-24ed2987 .uagb-taxomony-box{border-top-width: 1px;border-left-width: 1px;border-right-width: 1px;border-bottom-width: 1px;border-top-left-radius: 3px;border-top-right-radius: 3px;border-bottom-left-radius: 3px;border-bottom-right-radius: 3px;border-color: #E0E0E0;border-style: solid;}.uagb-block-24ed2987 .uagb-taxomony-box:hover{border-color: #E0E0E0;}@media only screen and (max-width: 976px) {.uagb-block-24ed2987.uagb-taxonomy-wrap.uagb-layout-grid{grid-template-columns: repeat(2, 1fr);}.uagb-block-24ed2987.uagb-taxonomy__outer-wrap.uagb-layout-grid{grid-template-columns: repeat(2, 1fr);}.uagb-block-24ed2987.uagb-layout-grid .uagb-taxomony-box{padding-left: 15px;padding-right: 15px;padding-top: 15px;padding-bottom: 15px;}.uagb-block-24ed2987 .uagb-taxomony-box{border-style: solid;border-color: #E0E0E0;}}@media only screen and (max-width: 767px) {.uagb-block-24ed2987.uagb-taxonomy__outer-wrap.uagb-layout-grid{grid-template-columns: repeat(1, 1fr);}.uagb-block-24ed2987.uagb-layout-grid .uagb-taxomony-box{padding-left: 15px;padding-right: 15px;padding-top: 15px;padding-bottom: 15px;}.uagb-block-24ed2987 .uagb-taxomony-box{border-style: solid;border-color: #E0E0E0;}}.uagb-block-3ee00f6a .uagb-ifb-icon{width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-ifb-icon > span{font-size: 30px;width: 30px;line-height: 30px;color: #333;}.uagb-block-3ee00f6a .uagb-ifb-icon svg{fill: #333;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap svg{width: 30px;height: 30px;line-height: 30px;font-size: 30px;color: #333;fill: #333;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-icon-wrap svg{line-height: 30px;font-size: 30px;color: #333;fill: #333;}.uagb-block-3ee00f6a .uagb-iconbox-icon-wrap{margin: auto;display: inline-flex;align-items: center;justify-content: center;box-sizing: content-box;width: 30px;height: 30px;line-height: 30px;padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap > svg{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-icon-wrap > svg{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-left-title-image svg{width: 30px;line-height: 30px;font-size: 30px;color: #333;fill: #333;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-right-title-image svg{width: 30px;line-height: 30px;font-size: 30px;color: #333;fill: #333;}.uagb-block-3ee00f6a .uagb-infobox__content-wrap .uagb-ifb-imgicon-wrap{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;}.uagb-block-3ee00f6a .uagb-infobox .uagb-ifb-image-content img{border-radius: 0px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap img{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;border-radius: 0px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-right-title-image > img{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;border-radius: 0px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-left-title-image > img{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;border-radius: 0px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content > img{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;border-radius: 0px;}.uagb-block-3ee00f6a .uagb-ifb-title-wrap .uagb-ifb-title-prefix{margin-bottom: 10px;margin-top: 5px;}.uagb-block-3ee00f6a.wp-block-uagb-info-box .uagb-ifb-title{margin-bottom: 10px;}.uagb-block-3ee00f6a.wp-block-uagb-info-box .uagb-ifb-desc{margin-bottom: 5px;margin-top: 0px;margin-left: 0px;margin-right: 0px;}.uagb-block-3ee00f6a .uagb-ifb-separator{width: 30%;border-top-width: 2px;border-top-color: #333;border-top-style: solid;margin-bottom: 0px;}.uagb-block-3ee00f6a .uagb-infobox__content-wrap .uagb-ifb-separator{width: 30%;border-top-width: 2px;border-top-color: #333;border-top-style: solid;}.uagb-block-3ee00f6a .uagb-ifb-align-icon-after{margin-left: 5px;}.uagb-block-3ee00f6a .uagb-ifb-align-icon-before{margin-right: 5px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content svg{box-sizing: content-box;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content img{box-sizing: content-box;}.uagb-block-3ee00f6a .uagb-infobox__content-wrap{text-align: left;}.uagb-block-3ee00f6a.uagb-infobox-icon-above-title{text-align: left;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg {margin-left: 5px;}[dir=rtl] .uagb-block-3ee00f6a .uagb-iconbox-icon-wrap{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap > svg{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-icon-wrap > svg{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap img{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-right-title-image > img{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-left-title-image > img{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content > img{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap{text-align: right;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox-icon-above-title{text-align: right;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg{margin-right: 5px;margin-left: 0px;}@media only screen and (max-width: 976px) {.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap > svg{width: 30px;height: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-icon-wrap > svg{line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content img{box-sizing: content-box;}.uagb-block-3ee00f6a .uagb-ifb-icon{width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-ifb-icon > span{font-size: 30px;width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-iconbox-icon-wrap{width: 30px;height: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-left-title-image > svg{width: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-right-title-image > svg{width: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg {margin-left: 5px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg{margin-right: 5px;margin-left: 0px;}}@media only screen and (max-width: 767px) {.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap > svg{width: 30px;height: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-icon-wrap > svg{line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-left-title-image > svg{width: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-right-title-image > svg{width: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content img{box-sizing: content-box;}.uagb-block-3ee00f6a .uagb-ifb-icon{width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-ifb-icon > span{font-size: 30px;width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-iconbox-icon-wrap{width: 30px;height: 30px;line-height: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg {margin-left: 5px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg{margin-right: 5px;margin-left: 0px;}}.uagb-block-3ee00f6a .uagb-ifb-icon{width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-ifb-icon > span{font-size: 30px;width: 30px;line-height: 30px;color: #333;}.uagb-block-3ee00f6a .uagb-ifb-icon svg{fill: #333;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap svg{width: 30px;height: 30px;line-height: 30px;font-size: 30px;color: #333;fill: #333;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-icon-wrap svg{line-height: 30px;font-size: 30px;color: #333;fill: #333;}.uagb-block-3ee00f6a .uagb-iconbox-icon-wrap{margin: auto;display: inline-flex;align-items: center;justify-content: center;box-sizing: content-box;width: 30px;height: 30px;line-height: 30px;padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap > svg{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-icon-wrap > svg{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-left-title-image svg{width: 30px;line-height: 30px;font-size: 30px;color: #333;fill: #333;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-right-title-image svg{width: 30px;line-height: 30px;font-size: 30px;color: #333;fill: #333;}.uagb-block-3ee00f6a .uagb-infobox__content-wrap .uagb-ifb-imgicon-wrap{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;}.uagb-block-3ee00f6a .uagb-infobox .uagb-ifb-image-content img{border-radius: 0px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap img{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;border-radius: 0px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-right-title-image > img{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;border-radius: 0px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-left-title-image > img{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;border-radius: 0px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content > img{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;border-radius: 0px;}.uagb-block-3ee00f6a .uagb-ifb-title-wrap .uagb-ifb-title-prefix{margin-bottom: 10px;margin-top: 5px;}.uagb-block-3ee00f6a.wp-block-uagb-info-box .uagb-ifb-title{margin-bottom: 10px;}.uagb-block-3ee00f6a.wp-block-uagb-info-box .uagb-ifb-desc{margin-bottom: 5px;margin-top: 0px;margin-left: 0px;margin-right: 0px;}.uagb-block-3ee00f6a .uagb-ifb-separator{width: 30%;border-top-width: 2px;border-top-color: #333;border-top-style: solid;margin-bottom: 0px;}.uagb-block-3ee00f6a .uagb-infobox__content-wrap .uagb-ifb-separator{width: 30%;border-top-width: 2px;border-top-color: #333;border-top-style: solid;}.uagb-block-3ee00f6a .uagb-ifb-align-icon-after{margin-left: 5px;}.uagb-block-3ee00f6a .uagb-ifb-align-icon-before{margin-right: 5px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content svg{box-sizing: content-box;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content img{box-sizing: content-box;}.uagb-block-3ee00f6a .uagb-infobox__content-wrap{text-align: left;}.uagb-block-3ee00f6a.uagb-infobox-icon-above-title{text-align: left;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg {margin-left: 5px;}[dir=rtl] .uagb-block-3ee00f6a .uagb-iconbox-icon-wrap{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap > svg{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-icon-wrap > svg{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap img{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-right-title-image > img{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-left-title-image > img{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content > img{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap{text-align: right;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox-icon-above-title{text-align: right;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg{margin-right: 5px;margin-left: 0px;}@media only screen and (max-width: 976px) {.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap > svg{width: 30px;height: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-icon-wrap > svg{line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content img{box-sizing: content-box;}.uagb-block-3ee00f6a .uagb-ifb-icon{width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-ifb-icon > span{font-size: 30px;width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-iconbox-icon-wrap{width: 30px;height: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-left-title-image > svg{width: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-right-title-image > svg{width: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg {margin-left: 5px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg{margin-right: 5px;margin-left: 0px;}}@media only screen and (max-width: 767px) {.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap > svg{width: 30px;height: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-icon-wrap > svg{line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-left-title-image > svg{width: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-right-title-image > svg{width: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content img{box-sizing: content-box;}.uagb-block-3ee00f6a .uagb-ifb-icon{width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-ifb-icon > span{font-size: 30px;width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-iconbox-icon-wrap{width: 30px;height: 30px;line-height: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg {margin-left: 5px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg{margin-right: 5px;margin-left: 0px;}}\";s:2:\"js\";s:0:\"\";s:18:\"current_block_list\";a:8:{i:0;s:13:\"uagb\/info-box\";i:1;s:10:\"core\/image\";i:2;s:12:\"core\/heading\";i:3;s:14:\"core\/paragraph\";i:4;s:11:\"core\/search\";i:5;s:14:\"uagb\/separator\";i:6;s:18:\"uagb\/taxonomy-list\";i:7;s:13:\"core\/archives\";}s:8:\"uag_flag\";b:1;s:11:\"uag_version\";s:10:\"1770034961\";s:6:\"gfonts\";a:0:{}s:10:\"gfonts_url\";s:0:\"\";s:12:\"gfonts_files\";a:0:{}s:14:\"uag_faq_layout\";b:0;}"],"_uag_css_file_name":["uag-css-21254.css"]},"uagb_featured_image_src":{"full":["https:\/\/www.opc.cat\/wp-content\/uploads\/2013\/09\/27-antibiotico-11.jpg",320,211,false],"thumbnail":["https:\/\/www.opc.cat\/wp-content\/uploads\/2013\/09\/27-antibiotico-11-150x150.jpg",150,150,true],"medium":["https:\/\/www.opc.cat\/wp-content\/uploads\/2013\/09\/27-antibiotico-11-300x198.jpg",300,198,true],"medium_large":["https:\/\/www.opc.cat\/wp-content\/uploads\/2013\/09\/27-antibiotico-11.jpg",320,211,false],"large":["https:\/\/www.opc.cat\/wp-content\/uploads\/2013\/09\/27-antibiotico-11.jpg",320,211,false],"1536x1536":["https:\/\/www.opc.cat\/wp-content\/uploads\/2013\/09\/27-antibiotico-11.jpg",320,211,false],"2048x2048":["https:\/\/www.opc.cat\/wp-content\/uploads\/2013\/09\/27-antibiotico-11.jpg",320,211,false]},"uagb_author_info":{"display_name":"opc","author_link":"https:\/\/www.opc.cat\/es\/author\/opc\/"},"uagb_comment_info":0,"uagb_excerpt":"Los antibi\u00f3ticos fueron uno de los grandes avances de la medicina moderna y, en justa correspondencia, su p\u00e9rdida de eficacia es uno de los grandes problemas de la contempor\u00e1nea. Cuanto m\u00e1s usamos \u2013y abusamos de\u2014 los antibi\u00f3ticos, m\u00e1s resistentes se hacen las bacterias a ellos, hasta el extremo de que buena parte de la mortalidad&hellip;","_links":{"self":[{"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/posts\/21254","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/comments?post=21254"}],"version-history":[{"count":0,"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/posts\/21254\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/media\/24563"}],"wp:attachment":[{"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/media?parent=21254"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/categories?post=21254"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/tags?post=21254"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}