{"id":21260,"date":"2013-09-19T12:53:00","date_gmt":"2013-09-19T10:53:00","guid":{"rendered":"https:\/\/www.opc.cat\/una-fuente-inagotable-de-celulas-madre-para-la-medicina-2\/"},"modified":"2013-09-19T12:53:00","modified_gmt":"2013-09-19T10:53:00","slug":"una-fuente-inagotable-de-celulas-madre-para-la-medicina-2","status":"publish","type":"post","link":"https:\/\/www.opc.cat\/es\/una-fuente-inagotable-de-celulas-madre-para-la-medicina-2\/","title":{"rendered":"Una fuente inagotable de c\u00e9lulas madre para la medicina"},"content":{"rendered":"<div class=\"separator\" style=\"clear: both; text-align: center;\">\n<a href=\"https:\/\/www.opc.cat\/wp-content\/uploads\/2013\/09\/27-celulas_madre.jpg\" imageanchor=\"1\" style=\"clear: left; float: left; margin-bottom: 1em; margin-right: 1em;\"><img decoding=\"async\" border=\"0\" src=\"https:\/\/www.opc.cat\/wp-content\/uploads\/2013\/09\/27-celulas_madre.jpg\" \/><\/a><\/div>\n<p>Cient\u00edficos de Israel han descubierto una fuente inagotable de c\u00e9lulas madre para la medicina. Y la han encontrado en los tejidos de los propios pacientes. Una de las grandes trabas para la aplicaci\u00f3n cl\u00ednica de las c\u00e9lulas madre iPS, las estrellas emergentes de la medicina regenerativa, es la ineficacia de su obtenci\u00f3n a partir de c\u00e9lulas de la piel: solo una min\u00fascula fracci\u00f3n de \u00e9stas, menos del 1%, logra retrasar su reloj para recuperar su primitiva condici\u00f3n de c\u00e9lulas madre, y por tanto su capacidad para regenerar cualquier tejido y \u00f3rgano del cuerpo. El nuevo trabajo identifica una forma de superar esa barrera y llevar la eficacia hasta casi el 100%.<\/p>\n<p>La tecnolog\u00eda de las c\u00e9lulas madre iPS, o de pluripotencia inducida, se ha desarrollado en los \u00faltimos a\u00f1os como una salida a los conflictos \u00e9ticos, pol\u00edticos y religiosos que suscitaron en la d\u00e9cada anterior las c\u00e9lulas madre embrionarias. Mientras que estas \u00faltimas requieren la destrucci\u00f3n de embriones humanos de dos semanas, las c\u00e9lulas iPS proceden de la reprogramaci\u00f3n de simples c\u00e9lulas de la piel de un paciente. Esto no solo evita el uso de embriones, sino que produce un material gen\u00e9ticamente id\u00e9ntico al paciente en cuesti\u00f3n, lo que evitar\u00e1 el rechazo en caso de serle trasplantado.<\/p>\n<p>La t\u00e9cnica de reprogramaci\u00f3n ideada por el investigador japon\u00e9s Shinya Yamanaka \u2014que recibi\u00f3 por ello el \u00faltimo premio Nobel de Medicina\u2014 sorprendi\u00f3 a la comunidad cient\u00edfica por su gran simplicidad. Solo requiere tratar las c\u00e9lulas de la piel con cuatro factores de transcripci\u00f3n, o genes que regulan a otros genes. La otra cara de la moneda es que esas c\u00e9lulas adultas son muy resistentes a abandonar su naturaleza diferenciada, dedicada a las peculiaridades del oficio de ser piel, y recuperar su primitiva condici\u00f3n pluripotente, capaz de convertirse en cualquier otro tipo celular.Jacob Hanna y sus colegas del Instituto Weizmann en Rehovot, Israel, han logrado ahora identificar lo que parece ser el principal impedimento para una conversi\u00f3n eficaz de las c\u00e9lulas adultas en c\u00e9lulas iPS. Se trata de un gen conservado en los mam\u00edferos, llamado Mbd3. Hanna muestra en la revista Nature que la inactivaci\u00f3n de ese gen, unida al procedimiento convencional de retrasar el reloj celular, permite a las c\u00e9lulas adultas \u2014ya sean de rat\u00f3n o de humano\u2014 convertirse en c\u00e9lulas iPS con una eficacia cercana al 100%. No solo funciona con la piel, sino tambi\u00e9n con otros tipos de tejido, lo que tambi\u00e9n incrementa las posibles fuentes de material para el futuro.<\/p>\n<p>Los fibroblastos, o c\u00e9lulas que van regenerando la piel, se convierten en c\u00e9lulas madre iPS con menos de 1% de eficiencia. Esta ineficacia \u201cest\u00e1 obstaculizando la generaci\u00f3n de diversos tipos celulares para la investigaci\u00f3n y la medicina\u201d, seg\u00fan reconocen en Nature los bi\u00f3logos del desarrollo Kyle Loh, de la Universidad de Stanford, y Bing Lim, del Instituto del Genoma de Singapur. Este es el obst\u00e1culo que pretende despejar el trabajo de los cient\u00edficos del Instituto Weizmann.<\/p>\n<p>Los cient\u00edficos han hallado ahora que los propios reprogramadores Oct4, Sox2, Klf4 y Myc, los llamados factores de Yamanaka en el mundillo, reclutan a su servicio a un gen represor, llamado Mbd3, que se dedica a reprimir a los mismos genes inmaduros que ellos est\u00e1n intentando activar. Y que basta inactivar a ese represor Mbd3 para que la balanza se desequilibre y la eficacia de la reprogramaci\u00f3n ascienda al 100%. En este tipo de trabalenguas viven sumidos los genetistas.Casi todas las c\u00e9lulas del cuerpo tienen el mismo genoma, una copia del genoma humano que han heredado del cigoto, la c\u00e9lula formada por fusi\u00f3n de un \u00f3vulo y un espermatozoide. Que una c\u00e9lula de la piel sea distinta de una del h\u00edgado o de una neurona se debe a que cada una tiene activos distintos factores de transcripci\u00f3n, o genes que regulan a otros genes. Esta organizaci\u00f3n jer\u00e1rquica de la regulaci\u00f3n gen\u00e9tica permite a unos pocos factores de transcripci\u00f3n regular grandes redes de genes subordinados, y en el fondo es la raz\u00f3n de que funcione la t\u00e9cnica de Yamanaka: que solo cuatro factores de transcripci\u00f3n, llamados Oct4, Sox2, Klf4 y Myc, basten para reprogramar c\u00e9lulas de la piel como c\u00e9lulas madre. Pero \u00bfpor qu\u00e9 la eficacia es tan baja?<\/p>\n<div style=\"text-align: right;\">\n<i>Fuente: <a href=\"http:\/\/sociedad.elpais.com\/sociedad\/2013\/09\/18\/actualidad\/1379534891_409306.html\" target=\"_blank\">El Pa\u00eds<\/a><\/i><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Cient\u00edficos de Israel han descubierto una fuente inagotable de c\u00e9lulas madre para la medicina. Y la han encontrado en los tejidos de los propios pacientes. Una de las grandes trabas para la aplicaci\u00f3n cl\u00ednica de las c\u00e9lulas madre iPS, las estrellas emergentes de la medicina regenerativa, es la ineficacia de su obtenci\u00f3n a partir de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":24572,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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