{"id":21264,"date":"2013-09-11T15:34:00","date_gmt":"2013-09-11T13:34:00","guid":{"rendered":"https:\/\/www.opc.cat\/investigadores-espanoles-obtienen-por-primera-vez-celulas-madre-embrionarias-en-ratones-2\/"},"modified":"2013-09-11T15:34:00","modified_gmt":"2013-09-11T13:34:00","slug":"investigadores-espanoles-obtienen-por-primera-vez-celulas-madre-embrionarias-en-ratones-2","status":"publish","type":"post","link":"https:\/\/www.opc.cat\/es\/investigadores-espanoles-obtienen-por-primera-vez-celulas-madre-embrionarias-en-ratones-2\/","title":{"rendered":"Investigadores espa\u00f1oles obtienen por primera vez c\u00e9lulas madre embrionarias en ratones"},"content":{"rendered":"<div class=\"separator\" style=\"clear: both; text-align: center;\">\n<a href=\"https:\/\/www.opc.cat\/wp-content\/uploads\/2013\/09\/investigadores-espa\u00f1oles.jpg\" imageanchor=\"1\" style=\"clear: right; float: right; margin-bottom: 1em; margin-left: 1em;\"><img decoding=\"async\" border=\"0\" src=\"https:\/\/www.opc.cat\/wp-content\/uploads\/2013\/09\/investigadores-espa\u00f1oles.jpg\" \/><\/a><\/div>\n<p>Investigadores espa\u00f1oles, liderados por Manuel Serrano, director del Programa de Oncolog\u00eda Molecular del Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), han logrado obtener por primera vez c\u00e9lulas madre embrionarias directamente en organismos vivos, ratones en este caso. Adem\u00e1s, estas c\u00e9lulas tienen una capacidad de diferenciaci\u00f3n mayor que las obtenidas hasta ahora en cultivos in vitro, las denominadas c\u00e9lulas madre pluripotente inducidas (IPS). Las inducidas in vivo por el equipo de Serrano llegan hasta un estadio embrionario m\u00e1s temprano, equivalente a embriones humanos de 72 horas de gestaci\u00f3n y s\u00f3lo 16 c\u00e9lulas y se comportan como c\u00e9lulas totipotentes: capaces de originar cualquiera de los tejidos del organismo \u2014como las IPS\u2014, pero adem\u00e1s otros que s\u00f3lo se producen en el embri\u00f3n, como la placenta, algo que hasta ahora no se hab\u00eda conseguido en el laboratorio.<\/p>\n<p>Los investigadores lograron inducir la formaci\u00f3n de pseudoembriones en las cavidades tor\u00e1cica y abdominal de los ratones, que presentaban las tres capas propias de los embriones de las que derivan todos los tejidos (ectodermo, mesodermo y endodermo), estructuras que soportan la formaci\u00f3n del embri\u00f3n, como el saco vitelino y vieron signos de formaci\u00f3n de c\u00e9lulas sangu\u00edneas.<\/p>\n<p>Este importante descubrimiento ampl\u00eda las aplicaciones de las c\u00e9lulas madre inducidas (IPS) en medicina regenerativa. \u00abCon los mismos cuatro genes que se reprograman las c\u00e9lulas adultas en placas de laboratorio, se consigue llegar m\u00e1s atr\u00e1s cuando se hace dentro del organismo, como si se mejorara elproceso de reprogramaci\u00f3n. Esto se traduce en mayor plasticidad celular. En vez de ser pluripotentes, es decir, con capacidad para diferenciarse en todos los tejidos del embri\u00f3n, estas c\u00e9lulas son totipotentes, lo que significa que adem\u00e1s originan tejidos de soporte embrionarios, como la placenta\u00bb, explica Mar\u00eda Abad, primera autora del trabajo. La ventaja, aclara la investigadora, es que \u00abse podr\u00edan tratar enfermedades placentarias. Y ya que son m\u00e1s potentes y pl\u00e1sticas, quiz\u00e1 tengan tambi\u00e9n mejorada la capacidad de diferenciaci\u00f3n en distintos \u00f3rganos respecto a las IPS, aunque esto est\u00e1 por ver\u00bb, aclara.<\/p>\n<p>En 2009, en los primeros momentos de la reprogramaci\u00f3n celular in vitro, el equipo de Manuel Serrano se plante\u00f3 si ser\u00eda posible hacerlo in vivo, sin necesidad de extraerlas del organismo y cultivarlas luego en una placa de laboratorio. Hoy la revista \u201cNature\u201d da a conocer el trabajo, que demuestra que es posible lograrlo utilizando el mismo \u201cc\u00f3ctel\u201d de cuatro genes que us\u00f3 el investigador japon\u00e9s Yamanaka para obtener por primera vez c\u00e9lulas madre embrionarias a partir de fribroblastos de la piel sin tener que recurrir a un embri\u00f3n. La sorpresa ha sido que no s\u00f3lo se puede, sino que estas c\u00e9lulas reprogramadas directamente en el interior de los ratones vivos est\u00e1n adem\u00e1s un paso por delante de las c\u00e9lulas pluripotentes inducidas (IPs) de Yamanaka. Lo explicaba Manuel Serrano el pasado mes de mayo en la Fundaci\u00f3n Jim\u00e9nez D\u00edaz, donde recogi\u00f3 el premio de este a\u00f1o de la Fundaci\u00f3n y pronunci\u00f3 la XLV lecci\u00f3n conmemorativa, con el t\u00edtulo \u201cNuevas fronteras de la reprogramaci\u00f3n celular\u201d. \u201cLa reprogramaci\u00f3n celular in vivo es posible\u201d, aunque gran parte de la comunidad cient\u00edfica cre\u00eda que no, dec\u00eda Marug\u00e1n, adelantando datos de su trabajo a\u00fan sin publicar.<\/p>\n<p>Medicina regenerativa Este descubrimiento, explicaba, \u201cabre la puerta a la regeneraci\u00f3n in situ en los tejidos, bien aplicando los factores de reprogramaci\u00f3n [genes] o con compuestos qu\u00edmicos, porque otra cosa que est\u00e1 por venir es la regeneraci\u00f3n libre de genes\u201d. Sus palabras evocaban la famosa obra de teatro de Jardiel Poncela, \u201cCuatro corazones con freno y marcha atr\u00e1s\u201d, la historia de cuatro personajes que que no s\u00f3lo se convierten en inmortales, sino que adem\u00e1s acaban rejuveneciendo.<\/p>\n<p>\u00bfSer\u00e1 posible en un futuro reparar los tejidos da\u00f1ados dentro del organismo, en definitiva \u201crejuvenecerlos\u201d? Aunque conceptualmente ahora se ha demostrado que es posible, \u201cestamos en el primer paso en un organismo inferior como el rat\u00f3n. Es un avance saber que se pueden reprogramar c\u00e9lulas en el mismo organismo\u201d, aclara Abad. \u201cLas IPs generadas in vitro hasta ahora se han diferenciado en numerosos tejidos [incluido el cerebro]. Sin embargo, el escollo principal es que esos distintos tejidos se integren en los \u00f3rganos diana y sean funcionales. Idealmente ese escollo se evitar\u00eda si se pudiera hacer todo el proceso de reprogramaci\u00f3n dentro del organismo y controlando el proceso de diferenciaci\u00f3n\u201d, explica Mar\u00eda Abad. De momento, aunque se trata de un primer paso importante, las aplicaciones pr\u00e1cticas est\u00e1n a\u00fan lejanas, advierte Abad.<\/p>\n<p>\u201cNuestras c\u00e9lulas madre sobreviven tambi\u00e9n fuera de los ratones, en cultivo, por lo que podr\u00edamos adem\u00e1s, manipularlas en el laboratorio\u201d, explica Abad, que adelanta que \u201cel siguiente paso es estudiar si estas nuevas c\u00e9lulas son capaces de generar de una forma m\u00e1s eficiente distintos tipos de tejido, como p\u00e1ncreas, h\u00edgado o ri\u00f1\u00f3n\u201d.<\/p>\n<p>El trabajo desarrollado en el CNIO ha contado con el apoyo del equipo de Miguel Manzanares, del Centro Nacional de Investigaciones Cardiovasculares (CNIC) y con la financiaci\u00f3n del Ministerio de Econom\u00eda y Competitividad, el European Research Council, la Comunidad de Madrid, y las Fundaciones Bot\u00edn, AXA y Ram\u00f3n Areces.<\/p>\n<div style=\"text-align: right;\">\nFuente: <a href=\"http:\/\/www.abc.es\/sociedad\/20130911\/abci-celulas-reprogramacion-vivo-cnio-201309111709.html\" target=\"_blank\">ABC<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Investigadores espa\u00f1oles, liderados por Manuel Serrano, director del Programa de Oncolog\u00eda Molecular del Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), han logrado obtener por primera vez c\u00e9lulas madre embrionarias directamente en organismos vivos, ratones en este caso. Adem\u00e1s, estas c\u00e9lulas tienen una capacidad de diferenciaci\u00f3n mayor que las obtenidas hasta ahora en cultivos in vitro, las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":24578,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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espa\u00f1oles, liderados por Manuel Serrano, director del Programa de Oncolog\u00eda Molecular del Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), han logrado obtener por primera vez c\u00e9lulas madre embrionarias directamente en organismos vivos, ratones en este caso. 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