{"id":21270,"date":"2013-09-04T15:46:00","date_gmt":"2013-09-04T13:46:00","guid":{"rendered":"https:\/\/www.opc.cat\/la-edad-esta-en-el-cerebro-2\/"},"modified":"2013-09-04T15:46:00","modified_gmt":"2013-09-04T13:46:00","slug":"la-edad-esta-en-el-cerebro-2","status":"publish","type":"post","link":"https:\/\/www.opc.cat\/es\/la-edad-esta-en-el-cerebro-2\/","title":{"rendered":"La edad est\u00e1 en el cerebro"},"content":{"rendered":"<div class=\"separator\" style=\"clear: both; text-align: center;\">\n<a href=\"http:\/\/3.bp.blogspot.com\/-sOwVxfXNvI8\/UkruwBZzHtI\/AAAAAAAAAJg\/JCWaD_Yy_8E\/s1600\/cerebro.jpg\" imageanchor=\"1\" style=\"clear: right; float: right; margin-bottom: 1em; margin-left: 1em;\"><img fetchpriority=\"high\" decoding=\"async\" border=\"0\" height=\"262\" src=\"https:\/\/www.opc.cat\/wp-content\/uploads\/2013\/09\/cerebro.jpg\" width=\"320\" \/><\/a><\/div>\n<p>En los \u00faltimos a\u00f1os, la sirtuina ha sido objeto de acalorados debates cient\u00edficos. Aunque muchos expertos avalan sus propiedades antienvejecimiento, los <a href=\"http:\/\/www.elmundo.es\/elmundosalud\/2011\/09\/21\/biociencia\/1316626071.html\">\u00faltimos estudios descartan que dicha sustancia sea capaz de conseguir tales efectos<\/a>. Los resultados son contradictorios.<\/p>\n<p>Ahora, un grupo de investigadores de la escuela de Medicina de la Universidad de Washington (Saint-Louis,Misuri, EEUU) asegura tener la respuesta definitiva. Seg\u00fan Shin-ichiro Imai, el principal autor de este trabajo, publicado en la revista <a href=\"http:\/\/www.cell.com\/cell-metabolism\/target=\">&#8216;Cell Metabolism&#8217;<\/a>, \u00abhemos identificado el mecanismo por el cual una prote\u00edna espec\u00edfica llamada SIRT1 consigue provocar en el celebro un retraso significativo en el envejecimiento y el aumento de la longevidad\u00bb. Ambos, a\u00f1ade, \u00abse han asociado con una dieta baja en calor\u00edas\u00bb.<\/p>\n<p>La asociaci\u00f3n entre la alimentaci\u00f3n y los a\u00f1os de vida no es nueva. El fil\u00f3sofo y cient\u00edfico japon\u00e9s Ekiken Kaibara describi\u00f3 por primera vez, en 1713, el concepto de control de la dieta como m\u00e9todo para lograr una buena salud y m\u00e1s longevidad. Quiz\u00e1s tambi\u00e9n lo puso en pr\u00e1ctica, ya que muri\u00f3 a los 84, una edad muy por encima de la media en el siglo XVIII.<\/p>\n<p>Desde entonces, los resultados de varios estudios realizados en modelos de ratones han apoyado esta teor\u00eda que relaciona una dieta baja en calor\u00edas con una vida m\u00e1s larga. Tal y como explica Ram\u00f3n Estruch, del Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN), \u00abhay mucha evidencia en este sentido, sobre todo en animales de experimentaci\u00f3n. Incluso se ha visto que en situaciones de carencia econ\u00f3mica (como el bloqueo en Cuba), en las que la ingesta cal\u00f3rica se reduce, disminuyen algunas enfermedades cardiovasculares y aumenta la longevidad\u00bb.<\/p>\n<p>Ahora, por primera vez, se descubre por qu\u00e9 ocurre. Imai y su equipo han observado que <a href=\"http:\/\/www.elmundo.es\/papel\/2008\/02\/22\/mujer\/2332019_impresora.html\">SIRT1<\/a> provoca actividad neuronal en zonas espec\u00edficas del hipot\u00e1lamo, lo que desencadena una serie de cambios f\u00edsicos en el m\u00fasculo esquel\u00e9tico, que adquiere m\u00e1s vigor y longevidad. \u00abVimos que en los ratones viejos que expresan SIRT1 en el cerebro, las estructuras musculares esquel\u00e9ticas se parecen al tejido muscular joven\u00bb, argumenta Imai. Es decir, ratones de 12 meses (lo que equivale a 70 a\u00f1os en los humanos) se muestran tan activos como los de cinco meses de edad.<\/p>\n<p>SIRT1 es una prote\u00edna ligada a los genes y, como tal, cada persona expresa m\u00e1s o menos en funci\u00f3n del ambiente que le rodea (la dieta seguida, la exposici\u00f3n solar, etc.). En el caso de los ratones estudiados por el grupo de Imai, algunos fueron modificados gen\u00e9ticamente para sobreproducir SIRT1 en los tejidos del cuerpo, mientras que otros fueron dise\u00f1ados para producir esta sustancia s\u00f3lo en el cerebro. Los resultados hablaban por s\u00ed mismos: \u00abS\u00f3lo los animales que sobreexpresan SIRT1 en el cerebro tuvieron una vida m\u00e1s prolongada, al igual que los ratones normales criados en reg\u00edmenes de restricci\u00f3n de calor\u00edas en la dieta\u00bb.<\/p>\n<p>En definitiva, el efecto antienvejecimiento de la sobreexpresi\u00f3n de SIRT1 es similar al de la restricci\u00f3n diet\u00e9tica. De hecho, los animales modificados gen\u00e9ticamente para producir m\u00e1s SIRT1 en el cerebro no tienen por qu\u00e9 reducir la ingesta de calor\u00edas para beneficiarse del efecto antienvejecimiento asociado a la sirtuina.<\/p>\n<p>Esta sustancia no s\u00f3lo se traduce en cambios del m\u00fasculo esquel\u00e9tico, los roedores experimentaron un sue\u00f1o m\u00e1s profundo y vivieron m\u00e1s. En los ratones machos, el promedio de vida aument\u00f3 en un 9% y en las hembras en un 16%. En humanos, equivaldr\u00eda a 13 o 14 a\u00f1os m\u00e1s para las mujeres y unos siete m\u00e1s para los hombres.<\/p>\n<p>Otro de los beneficios comprobados en este estudio fue el retraso de muerte por c\u00e1ncer en los ratones con sobreexpresi\u00f3n SIRT1 en el cerebro. En general, \u00abse retrasa el declive relacionado con la edad\u00bb.<\/p>\n<p>En vista de los hallazgos obtenidos, apunta Imai, dado que el envejecimiento est\u00e1 marcado en algunas \u00e1reas cerebrales del hipot\u00e1lamo, se plantea la &#8216;fantas\u00eda&#8217; de poder alargar la vida manipulando los n\u00facleos cerebrales.<\/p>\n<div style=\"text-align: right;\">\nFuente: <a href=\"http:\/\/www.elmundo.es\/elmundosalud\/2013\/09\/03\/neurociencia\/1378234436.html\" target=\"_blank\">El Mundo<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>En los \u00faltimos a\u00f1os, la sirtuina ha sido objeto de acalorados debates cient\u00edficos. Aunque muchos expertos avalan sus propiedades antienvejecimiento, los \u00faltimos estudios descartan que dicha sustancia sea capaz de conseguir tales efectos. Los resultados son contradictorios. Ahora, un grupo de investigadores de la escuela de Medicina de la Universidad de Washington (Saint-Louis,Misuri, EEUU) asegura [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":24587,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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los \u00faltimos a\u00f1os, la sirtuina ha sido objeto de acalorados debates cient\u00edficos. Aunque muchos expertos avalan sus propiedades antienvejecimiento, los \u00faltimos estudios descartan que dicha sustancia sea capaz de conseguir tales efectos. Los resultados son contradictorios. Ahora, un grupo de investigadores de la escuela de Medicina de la Universidad de Washington (Saint-Louis,Misuri, EEUU) asegura&hellip;","_links":{"self":[{"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/posts\/21270","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/comments?post=21270"}],"version-history":[{"count":0,"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/posts\/21270\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/media\/24587"}],"wp:attachment":[{"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/media?parent=21270"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/categories?post=21270"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/tags?post=21270"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}