{"id":21280,"date":"2013-08-28T13:05:00","date_gmt":"2013-08-28T11:05:00","guid":{"rendered":"https:\/\/www.opc.cat\/una-pastilla-para-no-olvidar-2\/"},"modified":"2013-08-28T13:05:00","modified_gmt":"2013-08-28T11:05:00","slug":"una-pastilla-para-no-olvidar-2","status":"publish","type":"post","link":"https:\/\/www.opc.cat\/es\/una-pastilla-para-no-olvidar-2\/","title":{"rendered":"Una pastilla para no olvidar"},"content":{"rendered":"<div class=\"separator\" style=\"clear: both; text-align: center;\">\n<a href=\"https:\/\/www.opc.cat\/wp-content\/uploads\/2013\/08\/memoria.jpeg\" imageanchor=\"1\" style=\"margin-left: 1em; margin-right: 1em;\"><img decoding=\"async\" border=\"0\" src=\"https:\/\/www.opc.cat\/wp-content\/uploads\/2013\/08\/memoria.jpeg\" \/><\/a><\/div>\n<div class=\"p1\">\nM\u00e1s all\u00e1 del Alzheimer, existe un hecho fisiol\u00f3gico que es pr\u00e1cticamente inevitable. Con la vejez, se va perdiendo la memoria y de ah\u00ed las preguntas reiteradas y el no retener cosas que antes se manten\u00edan en la mente sin tener que hacer ning\u00fan esfuerzo. No es algo que solo le ocurra a los humanos, tambi\u00e9n los roedores lo experimentan. Y de ah\u00ed que este modelo animal haya servido para descubrir un hallazgo que podr\u00eda ser el primer paso para encontrar una pastilla para no olvidar. Adi\u00f3s a los sudokus y a los ejercicios para mantener la mente en forma, bienvenida la p\u00edldora para mantener la memoria.<\/div>\n<div class=\"p1\">\n<\/div>\n<div class=\"p1\">\nDetr\u00e1s de esta idea que puede sonar a ciencia ficci\u00f3n est\u00e1 el Nobel Eric Kandel y su equipo de investigadores de la Universidad de Columbia, en EEUU. Sus hallazgos se publican hoy en la revista &#8216;Science Traslacional Medicine&#8217; y son sencillos de resumir: tras esa p\u00e9rdida de memoria asociada a la edad existe la deficiencia de una prote\u00edna. La consecuencia l\u00f3gica de este descubrimiento tambi\u00e9n en simple. Si dicha p\u00e9rdida de memoria se asocia a la p\u00e9rdida de una prote\u00edna, elevando artificialmente los niveles de esta \u00faltima se podr\u00eda conseguir que la memoria perdida volviera.<\/div>\n<div class=\"p1\">\n<\/div>\n<div class=\"p1\">\nNo se trata de un deseo inalcanzable. Los investigadores ya lo han conseguido en ratones. Y como se\u00f1ala a ELMUNDO.ES Scott Small, uno de los autores, el hipocampo \u2013donde se genera la prote\u00edna protagonista \u2013 de humanos y ratones es extraordinariamente similar. \u00abTanto los hombres como estos roedores desarrollan un perfil muy parecido de declive de la memoria asociado a la edad y lo que hemos demostrado es que en las dos especies los niveles de la prote\u00edna RbAp48 han disminuido en el hipocampo de los ejemplares mayores\u00bb, resume.<\/div>\n<div class=\"p1\">\n<\/div>\n<div class=\"p1\">\nEl estudio reci\u00e9n publicado consta de dos partes claramente diferenciadas. La primera se\u00f1ala que la prote\u00edna RbAp48 disminuye con el envejecimiento, tanto en ratones como en humanos. Para demostrarlo, los investigadores analizaron ocho cerebros sanos (no afectados por Alzheimer) de personas j\u00f3venes y mayores que hab\u00edan decidido donar su cerebro a la ciencia. Dentro del hipocampo \u2013 concretamente en una parte denominada circonvuloci\u00f3n dentada (DG, en sus siglas en ingl\u00e9s)-, la regi\u00f3n del cerebro donde se forman los recuerdos, los autoresencontraron 17 genes cuyos niveles variaban mucho seg\u00fan la edad del donante. El m\u00e1s afectado era el RbAp48, cuyos niveles se reduc\u00edan en casi el 50% en los cerebros envejecidos en comparaci\u00f3n con los m\u00e1s j\u00f3venes.<\/div>\n<div class=\"p1\">\nLa segunda parte del estudio es la que m\u00e1s implicaciones pr\u00e1cticas podr\u00eda tener. Una vez demostrado el hallazgo y que esta variaci\u00f3n tambi\u00e9n estaba presente en cerebros de rat\u00f3n, los investigadores fueron m\u00e1s all\u00e1 y se preguntaron qu\u00e9 pasar\u00eda en un cerebro viejo al que se le aumentara el nivel del gen reci\u00e9n identificado. Y lo que sucedi\u00f3 es que los ratones vivos a los que modificaron gen\u00e9ticamente para expresar la prote\u00edna que codifica ese gen y aumentar sus niveles no solo dejaron de perder memoria sino que recuperaron la misma capacidad cognitiva que los animales m\u00e1s j\u00f3venes.<\/div>\n<div class=\"p1\">\nEs obvio que esto a\u00fan no se ha probado en humanos pero, seg\u00fan Small, ya se est\u00e1 preparando el salto. Este investigador cree que es una \u00abexpectativa plausible\u00bb el desarrollar un f\u00e1rmaco que revierta la p\u00e9rdida de memoria asociada al envejecimiento. \u00abTeniendo una diana molecular v\u00e1lida, es posible desarrollar intervenciones alrededor de esta\u00bb, comenta.<\/div>\n<div class=\"p1\">\n<\/div>\n<div class=\"p2\">\n<b>Un proceso reversible<\/b><\/div>\n<div class=\"p1\">\n<\/div>\n<div class=\"p1\">\nLos neur\u00f3logos espa\u00f1oles comparten el entusiasmo de los autores y definen el hallazgo muy interesante. Guillermo Garc\u00eda Ribas, coordinador del Grupo de Conducta y Demencias de la Sociedad Espa\u00f1ola de Neurolog\u00eda y neur\u00f3logo en el Hospital Ram\u00f3n y Cajal de Madrid, cree que implica algo tan importante como que la p\u00e9rdida de memoria asociada al envejecimiento es reversible. \u00abHasta ahora, no sabemos muy bien qu\u00e9 hacer con las personas sanas que pierden memoria; igual que para el coraz\u00f3n recomendamos perder peso y hacer ejercicio, para el cerebro intuimos que es bueno tener una vida relacional plena, pero no tenemos nada que recetar\u00bb, explica el especialista.<\/div>\n<div class=\"p1\">\n<\/div>\n<div class=\"p1\">\nA partir de este estudio, se intuye la posibilidad de poder desarrollar una pastilla \u00abque no solo revierta los problemas de memoria, sino que equipare esta a la de los j\u00f3venes\u00bb. \u00abAunque suene a ciencia ficci\u00f3n, tiene posibilidades\u00bb, subraya.<\/div>\n<div class=\"p1\">\n<\/div>\n<div class=\"p1\">\nGarc\u00eda Ribas cree que, antes de que eso suceda, habr\u00e1 que ver qu\u00e9 tipo de f\u00e1rmaco es el que consigue aumentar los niveles del gen y cu\u00e1ndo habr\u00eda que empezar a suministrarlo a la poblaci\u00f3n.<\/div>\n<div class=\"p1\">\nLo que este experto no cree es que, a partir de este trabajo, se vayan a poder descartar casos dudosos del Alzheimer. \u00abLos m\u00e9dicos somos mejores diagnosticando enfermedades que estados sanos, se llegar\u00e1 antes a una prueba diagn\u00f3stica independiente del Alzheimer\u00bb, a\u00f1ade.<\/div>\n<div class=\"p1\">\n<\/div>\n<div class=\"p1\">\nSu colega Pedro Bermejo, director m\u00e9dico en IB Neuroclinics, cree que en el estudio falla la parte traslacional y habr\u00e1 que ver si los resultados se pueden traspasar a humanos. \u00abHay que coger los resultados con pinzas por el momento, pero sin duda se abre una l\u00ednea de creaci\u00f3n de nuevas dianas terap\u00e9uticas para tratar la p\u00e9rdida de memoria asociada al envejecimiento\u00bb, comenta.<\/div>\n<div class=\"p1\">\n<\/div>\n<p><\/p>\n<div class=\"p1\">\nEl neur\u00f3logo se\u00f1ala tambi\u00e9n que, si se llegara a conseguir la pastilla para revertir este problema \u2013que afecta al 100% de la poblaci\u00f3n que envejece- ser\u00eda tan grande el volumen de personas que habr\u00eda que tratar \u00abque no habr\u00eda sistema sanitario que pudiera soportarlo\u00bb.<\/div>\n<div class=\"p1\" style=\"text-align: right;\">\n<i>Fuente: <a href=\"http:\/\/www.elmundo.es\/elmundosalud\/2013\/08\/28\/neurociencia\/1377709641.html\" target=\"_blank\">El Mundo<\/a><\/i><\/div>\n","protected":false},"excerpt":{"rendered":"<p>M\u00e1s all\u00e1 del Alzheimer, existe un hecho fisiol\u00f3gico que es pr\u00e1cticamente inevitable. Con la vejez, se va perdiendo la memoria y de ah\u00ed las preguntas reiteradas y el no retener cosas que antes se manten\u00edan en la mente sin tener que hacer ning\u00fan esfuerzo. No es algo que solo le ocurra a los humanos, tambi\u00e9n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":24602,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[3200,3203],"tags":[3276],"class_list":["post-21280","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biocienciaysalud","category-congresos-profesionales-es","tag-neurociencias-es"],"spectra_custom_meta":{"_encloseme":["1"],"_thumbnail_id":["24602"],"_uag_page_assets":["a:9:{s:3:\"css\";s:42753:\".uagb-ifb-content>svg *{-webkit-transition:all 0.2s;-o-transition:all 0.2s;transition:all 0.2s}.uagb-ifb-content>svg,.uagb-ifb-content{display:inline-block}.uagb-ifb-content>svg{vertical-align:middle;width:inherit;height:inherit;font-style:initial}.uagb-ifb-content .uagb-ifb-icon-wrap svg{box-sizing:content-box;width:inherit;height:inherit}.uagb-ifb-button-wrapper:empty{display:none}div.uagb-ifb-button-wrapper a.uagb-infobox-cta-link,div.uagb-ifb-cta a.uagb-infobox-cta-link,.entry .entry-content a.uagb-infobox-cta-link,a.uagb-infobox-link-wrap,.entry .entry-content a.uagb-infobox-link-wrap{text-decoration:none;align-items:center}.uagb-infobox-icon-left-title.uagb-infobox-image-valign-middle .uagb-ifb-title-wrap,.uagb-infobox-icon-right-title.uagb-infobox-image-valign-middle .uagb-ifb-title-wrap,.uagb-infobox-image-valign-middle .uagb-ifb-icon-wrap,.uagb-infobox-image-valign-middle .uagb-ifb-image-content,.uagb-infobox-icon-left.uagb-infobox-image-valign-middle .uagb-ifb-content,.uagb-infobox-icon-right.uagb-infobox-image-valign-middle .uagb-ifb-content{-ms-flex-item-align:center;-webkit-align-self:center;align-self:center}.uagb-infobox-icon-left-title.uagb-infobox-image-valign-top .uagb-ifb-title-wrap,.uagb-infobox-icon-right-title.uagb-infobox-image-valign-top .uagb-ifb-title-wrap,.uagb-infobox-image-valign-top .uagb-ifb-icon-wrap,.uagb-infobox-image-valign-top .uagb-ifb-image-content,.uagb-infobox-icon-left.uagb-infobox-image-valign-top .uagb-ifb-content,.uagb-infobox-icon-right.uagb-infobox-image-valign-top .uagb-ifb-content{-webkit-align-self:self-start;align-self:self-start}.uagb-infobox-left{justify-content:flex-start;text-align:left;-webkit-box-pack:start;-ms-flex-pack:start;-webkit-justify-content:flex-start;-moz-box-pack:start}.uagb-infobox-center{justify-content:center;text-align:center;-webkit-box-pack:center;-ms-flex-pack:center;-webkit-justify-content:center;-moz-box-pack:center}.uagb-infobox-right{justify-content:flex-end;text-align:right;-webkit-box-pack:end;-ms-flex-pack:end;-webkit-justify-content:flex-end;-moz-box-pack:end}.uagb-infobox-icon-above-title.uagb-infobox__content-wrap,.uagb-infobox-icon-below-title.uagb-infobox__content-wrap{display:block;width:100%}.uagb-infobox-icon-left-title .uagb-ifb-content>svg,.uagb-infobox-icon-left .uagb-ifb-content>svg{margin-right:10px}.uagb-infobox-icon-right-title .uagb-ifb-content>svg,.uagb-infobox-icon-right .uagb-ifb-content>svg{margin-left:10px}.uagb-infobox-icon-left.uagb-infobox__content-wrap,.uagb-infobox-icon-right.uagb-infobox__content-wrap,.uagb-infobox-icon-left-title .uagb-ifb-left-title-image,.uagb-infobox-icon-right-title .uagb-ifb-right-title-image{display:-webkit-box;display:-ms-flexbox;display:-webkit-flex;display:-moz-box;display:flex;-js-display:flex}.uagb-infobox-icon-left-title .uagb-ifb-left-title-image .uagb-ifb-image-content,.uagb-infobox-icon-right-title .uagb-ifb-right-title-image .uagb-ifb-image-content,.uagb-infobox-icon-left .uagb-ifb-image-content,.uagb-infobox-icon-right .uagb-ifb-image-content{flex-shrink:0;line-height:0}.uagb-infobox-icon-left-title .uagb-ifb-left-title-image .uagb-ifb-title-wrap,.uagb-infobox-icon-right-title .uagb-ifb-right-title-image .uagb-ifb-title-wrap,.uagb-infobox-icon-left .uagb-ifb-content,.uagb-infobox-icon-right .uagb-ifb-content{flex-grow:1}.uagb-infobox-icon-right.uagb-infobox__content-wrap,.uagb-infobox-icon-right-title .uagb-ifb-right-title-image{-webkit-box-pack:end;-ms-flex-pack:end;-webkit-justify-content:flex-end;-moz-box-pack:end;justify-content:flex-end}.uagb-ifb-content img{position:relative;display:inline-block;line-height:0;width:auto;height:auto !important;max-width:100%;border-radius:inherit;-webkit-box-sizing:content-box;-moz-box-sizing:content-box;-webkit-border-radius:inherit}.uagb-infobox-module-link{position:absolute;top:0;right:0;bottom:0;left:0;z-index:4;width:100%;height:100%}.uagb-edit-mode .uagb-infobox-module-link{z-index:2}.uagb-infobox-link-icon-after{margin-right:0;margin-left:5px}.uagb-infobox-link-icon-before{margin-right:5px;margin-left:0}.uagb-infobox-link-icon{-webkit-transition:all 200ms linear;transition:all 200ms linear}.uagb-infobox__content-wrap{box-sizing:border-box;position:relative;width:100%;word-break:break-word;z-index:1}.uagb-ifb-separator{display:inline-block;margin:0;border-top-color:#333;border-top-style:solid;border-top-width:2px;line-height:0}.uagb-ifb-button-wrapper{line-height:1}.uagb-ifb-button-wrapper.uagb-ifb-button-type-text .uagb-infobox-cta-link.wp-block-button__link{background-color:unset;border:none}.uagb-ifb-button-wrapper.uagb-ifb-button-type-text .uagb-infobox-cta-link.wp-block-button__link:hover{background-color:unset;border-color:unset}.uagb-ifb-button-wrapper .uagb-infobox-cta-link{cursor:pointer}.uagb-ifb-button-wrapper .uagb-infobox-cta-link.wp-block-button__link{width:auto}.uagb-ifb-button-wrapper .wp-block-button__link svg,.uagb-ifb-button-wrapper .ast-outline-button svg{fill:currentColor}.uagb-infobox__content-wrap a{-webkit-box-shadow:none;box-shadow:none;text-decoration:none}.uagb-ifb-title-wrap{width:100%}.uagb-ifb-title{margin-block-start:0}.uagb-ifb-title-wrap .uagb-ifb-title-prefix{display:block;padding:0;margin:0}.uagb-infobox__content-wrap.uagb-infobox__content-wrap{position:relative}.uagb-ifb-content{width:100%}.uagb-infobox__content-wrap.uagb-infobox,.uagb-ifb-content,.uagb-ifb-title-wrap,.uagb-ifb-title-prefix *,svg.dashicon.dashicons-upload{z-index:1}a.uagb-infobox-link-wrap{color:inherit}.uagb-ifb-content p:empty{display:none}.uagb-infobox__content-wrap .uagb-ifb-content img{display:inline-block;max-width:100%}.uagb-infobox__content-wrap .uagb-ifb-content svg{display:inline-block}.uagb-infobox__content-wrap .uagb-ifb-icon-wrap,.uagb-infobox-icon-left .uagb-ifb-image-content,.uagb-infobox-icon-right .uagb-ifb-image-content{box-sizing:content-box}.uagb-infobox-cta-link>svg{vertical-align:middle;width:15px;height:15px;font-size:15px}.uagb-infobox-cta-link{display:inline-flex}.block-editor-page #wpwrap .uagb-infobox-cta-link svg,.uagb-infobox-cta-link svg{font-style:normal}.uagb-infobox-icon-left-title .uagb-ifb-icon-wrap,.uagb-infobox-icon-left .uagb-ifb-icon-wrap{margin-right:10px;line-height:0}.uagb-infobox-icon-right-title .uagb-ifb-icon-wrap,.uagb-infobox-icon-right .uagb-ifb-icon-wrap{margin-left:10px;line-height:0}html[dir=\"rtl\"] .uagb-infobox-icon-left-title .uagb-ifb-icon-wrap,html[dir=\"rtl\"] .uagb-infobox-icon-left .uagb-ifb-icon-wrap{margin-left:10px;line-height:0}html[dir=\"rtl\"] .uagb-infobox-icon-right-title .uagb-ifb-icon-wrap,html[dir=\"rtl\"] .uagb-infobox-icon-right .uagb-ifb-icon-wrap{margin-right:10px;line-height:0}html[dir=\"rtl\"] .uagb-infobox-left{justify-content:flex-end;text-align:right;-webkit-box-pack:end;-ms-flex-pack:end;-webkit-justify-content:flex-end;-moz-box-pack:end}html[dir=\"rtl\"] .uagb-infobox-right{justify-content:flex-start;text-align:left;-webkit-box-pack:start;-ms-flex-pack:start;-webkit-justify-content:flex-start;-moz-box-pack:start}.uagb-infobox-icon-left .uagb-ifb-left-right-wrap,.uagb-infobox-icon-right .uagb-ifb-left-right-wrap,.uagb-infobox-icon-left-title .uagb-ifb-left-title-image,.uagb-infobox-icon-right-title .uagb-ifb-right-title-image{display:-webkit-box;display:-ms-flexbox;display:flex}.uagb-infobox-icon-right .uagb-ifb-left-right-wrap,.uagb-infobox-icon-right-title .uagb-ifb-right-title-image{-webkit-box-pack:end;-ms-flex-pack:end;-webkit-justify-content:flex-end;-moz-box-pack:end;justify-content:flex-end}a.uagb-infbox__link-to-all{position:absolute;top:0;left:0;z-index:3;width:100%;height:100%;box-shadow:none;text-decoration:none;-webkit-box-shadow:none}@media only screen and (max-width: 976px){.uagb-infobox-stacked-tablet.uagb-infobox__content-wrap .uagb-ifb-image-content{padding:0;margin-bottom:20px}.uagb-infobox-stacked-tablet.uagb-reverse-order-tablet.uagb-infobox__content-wrap{display:-webkit-inline-box;display:-ms-inline-flexbox;display:-webkit-inline-flex;display:-moz-inline-box;display:inline-flex;flex-direction:column-reverse;-js-display:inline-flex;-webkit-box-orient:vertical;-webkit-box-direction:reverse;-ms-flex-direction:column-reverse;-webkit-flex-direction:column-reverse;-moz-box-orient:vertical;-moz-box-direction:reverse}.uagb-infobox-stacked-tablet.uagb-infobox__content-wrap .uagb-ifb-content,.uagb-infobox-stacked-tablet.uagb-infobox__content-wrap .uagb-ifb-icon-wrap,.uagb-infobox-stacked-tablet.uagb-infobox__content-wrap .uagb-ifb-image-content{display:block;width:100%;text-align:center}.uagb-infobox-stacked-tablet.uagb-infobox__content-wrap .uagb-ifb-icon-wrap,.uagb-infobox-stacked-tablet.uagb-infobox__content-wrap .uagb-ifb-image-content{margin-right:0;margin-left:0}.uagb-infobox-stacked-tablet.uagb-infobox__content-wrap{display:inline-block}.uagb-infobox-icon-left-title.uagb-infobox-stacked-tablet .uagb-ifb-image-content,.uagb-infobox-icon-left-title.uagb-infobox-stacked-tablet .uagb-ifb-icon-wrap,.uagb-infobox-icon-left.uagb-infobox-stacked-tablet .uagb-ifb-image-content,.uagb-infobox-icon-left.uagb-infobox-stacked-tablet .uagb-ifb-icon-wrap{margin-right:0}.uagb-infobox-icon-right-title.uagb-infobox-stacked-tablet .uagb-ifb-image-content,.uagb-infobox-icon-right-title.uagb-infobox-stacked-tablet .uagb-ifb-icon-wrap,.uagb-infobox-icon-right.uagb-infobox-stacked-tablet .uagb-ifb-image-content,.uagb-infobox-icon-right.uagb-infobox-stacked-tablet .uagb-ifb-icon-wrap{margin-left:0}.uagb-infobox-icon-left-title .uagb-ifb-separator{margin:10px 0}}@media screen and (max-width: 767px){.uagb-infobox-stacked-mobile.uagb-infobox__content-wrap{display:inline-block}.uagb-infobox-stacked-mobile.uagb-infobox__content-wrap .uagb-ifb-image-content,.uagb-infobox-stacked-mobile.uagb-infobox__content-wrap .uagb-ifb-icon-wrap{padding:0;margin-bottom:20px;margin-right:0;margin-left:0}.uagb-infobox-stacked-mobile.uagb-infobox__content-wrap.uagb-reverse-order-mobile{display:-webkit-inline-box;display:-ms-inline-flexbox;display:-webkit-inline-flex;display:-moz-inline-box;display:inline-flex;flex-direction:column-reverse;-js-display:inline-flex;-webkit-box-orient:vertical;-webkit-box-direction:reverse;-ms-flex-direction:column-reverse;-webkit-flex-direction:column-reverse;-moz-box-orient:vertical;-moz-box-direction:reverse}.uagb-infobox-stacked-mobile.uagb-infobox__content-wrap .uagb-ifb-image-content,.uagb-infobox-stacked-mobile.uagb-infobox__content-wrap .uagb-ifb-icon-wrap,.uagb-infobox-stacked-mobile.uagb-infobox__content-wrap .uagb-ifb-content{display:block;width:100%;text-align:center}.uagb-infobox-icon-left-title.uagb-infobox-stacked-mobile .uagb-ifb-image-content,.uagb-infobox-icon-left-title.uagb-infobox-stacked-mobile .uagb-ifb-icon-wrap,.uagb-infobox-icon-left.uagb-infobox-stacked-mobile .uagb-ifb-image-content,.uagb-infobox-icon-left.uagb-infobox-stacked-mobile .uagb-ifb-icon-wrap{margin-right:0}.uagb-infobox-icon-right-title.uagb-infobox-stacked-mobile .uagb-ifb-image-content,.uagb-infobox-icon-right-title.uagb-infobox-stacked-mobile .uagb-ifb-icon-wrap,.uagb-infobox-icon-right.uagb-infobox-stacked-mobile .uagb-ifb-image-content,.uagb-infobox-icon-right.uagb-infobox-stacked-mobile .uagb-ifb-icon-wrap{margin-left:0}.uagb-infobox-icon-left-title .uagb-ifb-separator{margin:10px 0}}.uagb-ifb-icon svg{width:inherit;height:inherit;vertical-align:middle}.uagb-ifb-button-icon{height:15px;width:15px;font-size:15px;vertical-align:middle}.uagb-ifb-button-icon svg{height:inherit;width:inherit;display:inline-block}.uagb-ifb-button-icon.uagb-ifb-align-icon-after{float:right}.uagb-ifb-cta-button{display:inline-block}.uagb-disable-link{pointer-events:none}@media only screen and (min-width: 977px){.uagb-infobox-margin-wrapper{display:flex}}.uagb-ifb-content .uagb-ifb-desc p:last-child{margin-bottom:0}\n.uagb-block-3ee00f6a .uagb-ifb-icon{width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-ifb-icon > span{font-size: 30px;width: 30px;line-height: 30px;color: #333;}.uagb-block-3ee00f6a .uagb-ifb-icon svg{fill: #333;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap svg{width: 30px;height: 30px;line-height: 30px;font-size: 30px;color: #333;fill: #333;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-icon-wrap svg{line-height: 30px;font-size: 30px;color: #333;fill: #333;}.uagb-block-3ee00f6a .uagb-iconbox-icon-wrap{margin: auto;display: inline-flex;align-items: center;justify-content: center;box-sizing: content-box;width: 30px;height: 30px;line-height: 30px;padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap > svg{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-icon-wrap > svg{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-left-title-image svg{width: 30px;line-height: 30px;font-size: 30px;color: #333;fill: #333;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-right-title-image svg{width: 30px;line-height: 30px;font-size: 30px;color: #333;fill: #333;}.uagb-block-3ee00f6a .uagb-infobox__content-wrap .uagb-ifb-imgicon-wrap{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;}.uagb-block-3ee00f6a .uagb-infobox .uagb-ifb-image-content img{border-radius: 0px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap img{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;border-radius: 0px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-right-title-image > img{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;border-radius: 0px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-left-title-image > img{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;border-radius: 0px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content > img{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;border-radius: 0px;}.uagb-block-3ee00f6a .uagb-ifb-title-wrap .uagb-ifb-title-prefix{margin-bottom: 10px;margin-top: 5px;}.uagb-block-3ee00f6a.wp-block-uagb-info-box .uagb-ifb-title{margin-bottom: 10px;}.uagb-block-3ee00f6a.wp-block-uagb-info-box .uagb-ifb-desc{margin-bottom: 5px;margin-top: 0px;margin-left: 0px;margin-right: 0px;}.uagb-block-3ee00f6a .uagb-ifb-separator{width: 30%;border-top-width: 2px;border-top-color: #333;border-top-style: solid;margin-bottom: 0px;}.uagb-block-3ee00f6a .uagb-infobox__content-wrap .uagb-ifb-separator{width: 30%;border-top-width: 2px;border-top-color: #333;border-top-style: solid;}.uagb-block-3ee00f6a .uagb-ifb-align-icon-after{margin-left: 5px;}.uagb-block-3ee00f6a .uagb-ifb-align-icon-before{margin-right: 5px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content svg{box-sizing: content-box;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content img{box-sizing: content-box;}.uagb-block-3ee00f6a .uagb-infobox__content-wrap{text-align: left;}.uagb-block-3ee00f6a.uagb-infobox-icon-above-title{text-align: left;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg {margin-left: 5px;}[dir=rtl] .uagb-block-3ee00f6a .uagb-iconbox-icon-wrap{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap > svg{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-icon-wrap > svg{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap img{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-right-title-image > img{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-left-title-image > img{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content > img{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap{text-align: right;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox-icon-above-title{text-align: right;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg{margin-right: 5px;margin-left: 0px;}@media only screen and (max-width: 976px) {.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap > svg{width: 30px;height: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-icon-wrap > svg{line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content img{box-sizing: content-box;}.uagb-block-3ee00f6a .uagb-ifb-icon{width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-ifb-icon > span{font-size: 30px;width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-iconbox-icon-wrap{width: 30px;height: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-left-title-image > svg{width: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-right-title-image > svg{width: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg {margin-left: 5px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg{margin-right: 5px;margin-left: 0px;}}@media only screen and (max-width: 767px) {.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap > svg{width: 30px;height: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-icon-wrap > svg{line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-left-title-image > svg{width: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-right-title-image > svg{width: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content img{box-sizing: content-box;}.uagb-block-3ee00f6a .uagb-ifb-icon{width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-ifb-icon > span{font-size: 30px;width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-iconbox-icon-wrap{width: 30px;height: 30px;line-height: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg {margin-left: 5px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg{margin-right: 5px;margin-left: 0px;}}.uag-blocks-common-selector{z-index:var(--z-index-desktop) !important}@media (max-width: 976px){.uag-blocks-common-selector{z-index:var(--z-index-tablet) !important}}@media (max-width: 767px){.uag-blocks-common-selector{z-index:var(--z-index-mobile) !important}}\n.wp-block-uagb-separator{text-align:center;box-sizing:border-box;line-height:0}.wp-block-uagb-separator__inner{display:inline-block}.wp-block-uagb-separator:not(.wp-block-uagb-separator--text):not(.wp-block-uagb-separator--icon) .wp-block-uagb-separator__inner{border-top-style:solid;-webkit-mask:var(--my-background-image);-webkit-mask-size:38px 100%;-webkit-mask-repeat:repeat-x}.wp-block-uagb-separator--text .wp-block-uagb-separator__inner,.wp-block-uagb-separator--icon .wp-block-uagb-separator__inner{display:flex;justify-content:center;align-items:center;margin:0 auto}.wp-block-uagb-separator--text .wp-block-uagb-separator__inner::before,.wp-block-uagb-separator--icon .wp-block-uagb-separator__inner::before{display:block;content:\"\";border-bottom:0;flex-grow:1;border-top-color:#333;border-top-style:solid;-webkit-mask:var(--my-background-image);-webkit-mask-size:38px 100%;-webkit-mask-repeat:repeat-x}.wp-block-uagb-separator--text .wp-block-uagb-separator__inner::after,.wp-block-uagb-separator--icon .wp-block-uagb-separator__inner::after{display:block;content:\"\";border-bottom:0;flex-grow:1;border-top-color:#333;border-top-style:solid;-webkit-mask:var(--my-background-image);-webkit-mask-size:38px 100%;-webkit-mask-repeat:repeat-x}.wp-block-uagb-separator--icon .wp-block-uagb-separator-element svg{font-size:30px;color:#333;fill:#333;width:30px;height:30px;line-height:30px;max-width:none}.wp-block-uagb-separator--text .wp-block-uagb-separator-element .uagb-html-tag{word-break:initial;margin:0}\n.uagb-block-474a455e.wp-block-uagb-separator{text-align: center;}.uagb-block-474a455e.wp-block-uagb-separator--text .wp-block-uagb-separator-element .uagb-html-tag{font-style: normal;line-height: 1em;}.uagb-block-474a455e.wp-block-uagb-separator:not(.wp-block-uagb-separator--text):not(.wp-block-uagb-separator--icon) .wp-block-uagb-separator__inner{-webkit-mask-size: 5px 100%;border-top-width: 3px;width: 100%;border-top-color: #eeeeee;border-top-style: solid;margin-top: 5px;margin-bottom: 5px;}@media only screen and (max-width: 976px) {.uagb-block-474a455e.wp-block-uagb-separator{text-align: center;}.uagb-block-474a455e.wp-block-uagb-separator--text .wp-block-uagb-separator-element .uagb-html-tag{font-style: normal;margin-bottom: initial;line-height: 1em;}.uagb-block-474a455e.wp-block-uagb-separator:not(.wp-block-uagb-separator--text):not(.wp-block-uagb-separator--icon) .wp-block-uagb-separator__inner{-webkit-mask-size: 5px 100%;width: 100%;border-top-color: #eeeeee;border-top-style: solid;margin-top: 5px;margin-bottom: 5px;}}@media only screen and (max-width: 767px) {.uagb-block-474a455e.wp-block-uagb-separator{text-align: center;}.uagb-block-474a455e.wp-block-uagb-separator--text .wp-block-uagb-separator-element .uagb-html-tag{font-style: normal;margin-bottom: initial;line-height: 1em;}.uagb-block-474a455e.wp-block-uagb-separator:not(.wp-block-uagb-separator--text):not(.wp-block-uagb-separator--icon) .wp-block-uagb-separator__inner{-webkit-mask-size: 5px 100%;width: 100%;border-top-color: #eeeeee;border-top-style: solid;margin-top: 5px;margin-bottom: 5px;}}.uagb-block-474a455e.wp-block-uagb-separator{text-align: center;}.uagb-block-474a455e.wp-block-uagb-separator--text .wp-block-uagb-separator-element .uagb-html-tag{font-style: normal;line-height: 1em;}.uagb-block-474a455e .uagb-separator-spacing-wrapper{margin-top: 0px;margin-right: 0px;margin-bottom: 0px;margin-left: 0px;padding-top: 0px;padding-right: 0px;padding-bottom: 0px;padding-left: 0px;}.uagb-block-474a455e.wp-block-uagb-separator:not(.wp-block-uagb-separator--text):not(.wp-block-uagb-separator--icon) .wp-block-uagb-separator__inner{-webkit-mask-size: 5px 100%;border-top-width: 3px;width: 100%;border-top-color: #eeeeee;border-top-style: solid;margin-top: 5px;margin-bottom: 5px;}@media only screen and (max-width: 976px) {.uagb-block-474a455e.wp-block-uagb-separator{text-align: center;}.uagb-block-474a455e.wp-block-uagb-separator--text .wp-block-uagb-separator-element .uagb-html-tag{font-style: normal;margin-bottom: initial;line-height: 1em;}.uagb-block-474a455e.wp-block-uagb-separator:not(.wp-block-uagb-separator--text):not(.wp-block-uagb-separator--icon) .wp-block-uagb-separator__inner{-webkit-mask-size: 5px 100%;width: 100%;border-top-color: #eeeeee;border-top-style: solid;margin-top: 5px;margin-bottom: 5px;}}@media only screen and (max-width: 767px) {.uagb-block-474a455e.wp-block-uagb-separator{text-align: center;}.uagb-block-474a455e.wp-block-uagb-separator--text .wp-block-uagb-separator-element .uagb-html-tag{font-style: normal;margin-bottom: initial;line-height: 1em;}.uagb-block-474a455e.wp-block-uagb-separator:not(.wp-block-uagb-separator--text):not(.wp-block-uagb-separator--icon) .wp-block-uagb-separator__inner{-webkit-mask-size: 5px 100%;width: 100%;border-top-color: #eeeeee;border-top-style: solid;margin-top: 5px;margin-bottom: 5px;}}.uagb-block-474a455e.wp-block-uagb-separator{text-align: center;}.uagb-block-474a455e.wp-block-uagb-separator--text .wp-block-uagb-separator-element .uagb-html-tag{font-style: normal;line-height: 1em;}.uagb-block-474a455e.wp-block-uagb-separator:not(.wp-block-uagb-separator--text):not(.wp-block-uagb-separator--icon) .wp-block-uagb-separator__inner{-webkit-mask-size: 5px 100%;border-top-width: 3px;width: 100%;border-top-color: #eeeeee;border-top-style: solid;margin-top: 5px;margin-bottom: 5px;}@media only screen and (max-width: 976px) {.uagb-block-474a455e.wp-block-uagb-separator{text-align: center;}.uagb-block-474a455e.wp-block-uagb-separator--text .wp-block-uagb-separator-element .uagb-html-tag{font-style: normal;margin-bottom: initial;line-height: 1em;}.uagb-block-474a455e.wp-block-uagb-separator:not(.wp-block-uagb-separator--text):not(.wp-block-uagb-separator--icon) .wp-block-uagb-separator__inner{-webkit-mask-size: 5px 100%;width: 100%;border-top-color: #eeeeee;border-top-style: solid;margin-top: 5px;margin-bottom: 5px;}}@media only screen and (max-width: 767px) {.uagb-block-474a455e.wp-block-uagb-separator{text-align: center;}.uagb-block-474a455e.wp-block-uagb-separator--text .wp-block-uagb-separator-element .uagb-html-tag{font-style: normal;margin-bottom: initial;line-height: 1em;}.uagb-block-474a455e.wp-block-uagb-separator:not(.wp-block-uagb-separator--text):not(.wp-block-uagb-separator--icon) .wp-block-uagb-separator__inner{-webkit-mask-size: 5px 100%;width: 100%;border-top-color: #eeeeee;border-top-style: solid;margin-top: 5px;margin-bottom: 5px;}}.uagb-tax-not-available{padding:10px;border:1px solid;text-align:center}.uagb-layout-list .uagb-list-wrap{margin-left:10px}.uagb-taxonomy__outer-wrap{margin-bottom:20px}ul.uagb-taxonomy-list-children{margin-bottom:0}.uagb-tax-link h1,.uagb-tax-link h2,.uagb-tax-link h3,.uagb-tax-link h4,.uagb-tax-link h5,.uagb-tax-link h6{margin-top:unset}\n.uagb-block-24ed2987.uagb-taxonomy__outer-wrap.uagb-layout-grid{display: grid;grid-template-columns: repeat(2, 1fr);grid-column-gap: 20px;grid-row-gap: 20px;}.uagb-block-24ed2987.uagb-layout-grid .uagb-taxomony-box{padding-left: 10px;padding-right: 10px;padding-top: 10px;padding-bottom: 10px;grid-column-gap: 20px;background-color: #f5f5f5;text-align: left;box-shadow: 0px 0px   #00000070 ;}.uagb-block-24ed2987.uagb-layout-grid .uagb-tax-title{font-weight: 500;font-size: 18px;line-height: 1.2em;letter-spacing: 0px;color: #3b3b3b;margin-bottom: 5px;}.uagb-block-24ed2987.uagb-layout-grid .uagb-tax-link{color: #777777;}.uagb-block-24ed2987.uagb-layout-list .uagb-tax-list{list-style: disc;color: #3b3b3b;}.uagb-block-24ed2987.uagb-layout-list .uagb-tax-list:hover{color: #3b3b3b;}.uagb-block-24ed2987.uagb-layout-list .uagb-tax-link-wrap:hover{color: #3b3b3b;}.uagb-block-24ed2987.uagb-layout-list .uagb-tax-list a.uagb-tax-link{color: #3b3b3b;}.uagb-block-24ed2987.uagb-layout-list .uagb-tax-list a.uagb-tax-link:hover{color: #3b3b3b;}.uagb-block-24ed2987.uagb-layout-list .uagb-tax-list .uagb-tax-link-wrap{margin-bottom: 10px;}.uagb-block-24ed2987 .uagb-taxonomy-wrap.uagb-layout-grid{display: grid;grid-template-columns: repeat(2, 1fr);grid-column-gap: 20px;grid-row-gap: 20px;}.uagb-block-24ed2987 .uagb-layout-grid .uagb-taxomony-box{padding-left: 10px;padding-right: 10px;padding-top: 10px;padding-bottom: 10px;grid-column-gap: 20px;background-color: #f5f5f5;text-align: left;box-shadow: 0px 0px   #00000070 ;}.uagb-block-24ed2987 .uagb-layout-grid .uagb-tax-title{font-weight: 500;font-size: 18px;line-height: 1.2em;letter-spacing: 0px;color: #3b3b3b;margin-bottom: 5px;}.uagb-block-24ed2987 .uagb-layout-grid .uagb-tax-link{color: #777777;}.uagb-block-24ed2987 .uagb-layout-list .uagb-tax-list{list-style: disc;color: #3b3b3b;}.uagb-block-24ed2987 .uagb-layout-list .uagb-tax-list:hover{color: #3b3b3b;}.uagb-block-24ed2987 .uagb-layout-list .uagb-tax-list a.uagb-tax-link{color: #3b3b3b;}.uagb-block-24ed2987 .uagb-layout-list .uagb-tax-list a.uagb-tax-link:hover{color: #3b3b3b;}.uagb-block-24ed2987 .uagb-layout-list .uagb-tax-list .uagb-tax-link-wrap{margin-bottom: 10px;}.uagb-block-24ed2987.uagb-layout-list .uagb-tax-separator:hover{border-top-color: #b2b4b5;}.uagb-block-24ed2987 .uagb-taxomony-box{border-top-width: 1px;border-left-width: 1px;border-right-width: 1px;border-bottom-width: 1px;border-top-left-radius: 3px;border-top-right-radius: 3px;border-bottom-left-radius: 3px;border-bottom-right-radius: 3px;border-color: #E0E0E0;border-style: solid;}.uagb-block-24ed2987 .uagb-taxomony-box:hover{border-color: #E0E0E0;}@media only screen and (max-width: 976px) {.uagb-block-24ed2987.uagb-taxonomy-wrap.uagb-layout-grid{grid-template-columns: repeat(2, 1fr);}.uagb-block-24ed2987.uagb-taxonomy__outer-wrap.uagb-layout-grid{grid-template-columns: repeat(2, 1fr);}.uagb-block-24ed2987.uagb-layout-grid .uagb-taxomony-box{padding-left: 15px;padding-right: 15px;padding-top: 15px;padding-bottom: 15px;}.uagb-block-24ed2987 .uagb-taxomony-box{border-style: solid;border-color: #E0E0E0;}}@media only screen and (max-width: 767px) {.uagb-block-24ed2987.uagb-taxonomy__outer-wrap.uagb-layout-grid{grid-template-columns: repeat(1, 1fr);}.uagb-block-24ed2987.uagb-layout-grid .uagb-taxomony-box{padding-left: 15px;padding-right: 15px;padding-top: 15px;padding-bottom: 15px;}.uagb-block-24ed2987 .uagb-taxomony-box{border-style: solid;border-color: #E0E0E0;}}.uagb-block-3ee00f6a .uagb-ifb-icon{width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-ifb-icon > span{font-size: 30px;width: 30px;line-height: 30px;color: #333;}.uagb-block-3ee00f6a .uagb-ifb-icon svg{fill: #333;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap svg{width: 30px;height: 30px;line-height: 30px;font-size: 30px;color: #333;fill: #333;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-icon-wrap svg{line-height: 30px;font-size: 30px;color: #333;fill: #333;}.uagb-block-3ee00f6a .uagb-iconbox-icon-wrap{margin: auto;display: inline-flex;align-items: center;justify-content: center;box-sizing: content-box;width: 30px;height: 30px;line-height: 30px;padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap > svg{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-icon-wrap > svg{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-left-title-image svg{width: 30px;line-height: 30px;font-size: 30px;color: #333;fill: #333;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-right-title-image svg{width: 30px;line-height: 30px;font-size: 30px;color: #333;fill: #333;}.uagb-block-3ee00f6a .uagb-infobox__content-wrap .uagb-ifb-imgicon-wrap{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;}.uagb-block-3ee00f6a .uagb-infobox .uagb-ifb-image-content img{border-radius: 0px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap img{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;border-radius: 0px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-right-title-image > img{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;border-radius: 0px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-left-title-image > img{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;border-radius: 0px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content > img{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;border-radius: 0px;}.uagb-block-3ee00f6a .uagb-ifb-title-wrap .uagb-ifb-title-prefix{margin-bottom: 10px;margin-top: 5px;}.uagb-block-3ee00f6a.wp-block-uagb-info-box .uagb-ifb-title{margin-bottom: 10px;}.uagb-block-3ee00f6a.wp-block-uagb-info-box .uagb-ifb-desc{margin-bottom: 5px;margin-top: 0px;margin-left: 0px;margin-right: 0px;}.uagb-block-3ee00f6a .uagb-ifb-separator{width: 30%;border-top-width: 2px;border-top-color: #333;border-top-style: solid;margin-bottom: 0px;}.uagb-block-3ee00f6a .uagb-infobox__content-wrap .uagb-ifb-separator{width: 30%;border-top-width: 2px;border-top-color: #333;border-top-style: solid;}.uagb-block-3ee00f6a .uagb-ifb-align-icon-after{margin-left: 5px;}.uagb-block-3ee00f6a .uagb-ifb-align-icon-before{margin-right: 5px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content svg{box-sizing: content-box;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content img{box-sizing: content-box;}.uagb-block-3ee00f6a .uagb-infobox__content-wrap{text-align: left;}.uagb-block-3ee00f6a.uagb-infobox-icon-above-title{text-align: left;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg {margin-left: 5px;}[dir=rtl] .uagb-block-3ee00f6a .uagb-iconbox-icon-wrap{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap > svg{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-icon-wrap > svg{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap img{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-right-title-image > img{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-left-title-image > img{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content > img{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap{text-align: right;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox-icon-above-title{text-align: right;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg{margin-right: 5px;margin-left: 0px;}@media only screen and (max-width: 976px) {.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap > svg{width: 30px;height: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-icon-wrap > svg{line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content img{box-sizing: content-box;}.uagb-block-3ee00f6a .uagb-ifb-icon{width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-ifb-icon > span{font-size: 30px;width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-iconbox-icon-wrap{width: 30px;height: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-left-title-image > svg{width: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-right-title-image > svg{width: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg {margin-left: 5px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg{margin-right: 5px;margin-left: 0px;}}@media only screen and (max-width: 767px) {.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap > svg{width: 30px;height: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-icon-wrap > svg{line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-left-title-image > svg{width: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-right-title-image > svg{width: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content img{box-sizing: content-box;}.uagb-block-3ee00f6a .uagb-ifb-icon{width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-ifb-icon > span{font-size: 30px;width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-iconbox-icon-wrap{width: 30px;height: 30px;line-height: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg {margin-left: 5px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg{margin-right: 5px;margin-left: 0px;}}.uagb-block-3ee00f6a .uagb-ifb-icon{width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-ifb-icon > span{font-size: 30px;width: 30px;line-height: 30px;color: #333;}.uagb-block-3ee00f6a .uagb-ifb-icon svg{fill: #333;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap svg{width: 30px;height: 30px;line-height: 30px;font-size: 30px;color: #333;fill: #333;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-icon-wrap svg{line-height: 30px;font-size: 30px;color: #333;fill: #333;}.uagb-block-3ee00f6a .uagb-iconbox-icon-wrap{margin: auto;display: inline-flex;align-items: center;justify-content: center;box-sizing: content-box;width: 30px;height: 30px;line-height: 30px;padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap > svg{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-icon-wrap > svg{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-left-title-image svg{width: 30px;line-height: 30px;font-size: 30px;color: #333;fill: #333;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-right-title-image svg{width: 30px;line-height: 30px;font-size: 30px;color: #333;fill: #333;}.uagb-block-3ee00f6a .uagb-infobox__content-wrap .uagb-ifb-imgicon-wrap{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;}.uagb-block-3ee00f6a .uagb-infobox .uagb-ifb-image-content img{border-radius: 0px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap img{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;border-radius: 0px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-right-title-image > img{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;border-radius: 0px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-left-title-image > img{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;border-radius: 0px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content > img{padding-left: 0px;padding-right: 0px;padding-top: 0px;padding-bottom: 39px;border-radius: 0px;}.uagb-block-3ee00f6a .uagb-ifb-title-wrap .uagb-ifb-title-prefix{margin-bottom: 10px;margin-top: 5px;}.uagb-block-3ee00f6a.wp-block-uagb-info-box .uagb-ifb-title{margin-bottom: 10px;}.uagb-block-3ee00f6a.wp-block-uagb-info-box .uagb-ifb-desc{margin-bottom: 5px;margin-top: 0px;margin-left: 0px;margin-right: 0px;}.uagb-block-3ee00f6a .uagb-ifb-separator{width: 30%;border-top-width: 2px;border-top-color: #333;border-top-style: solid;margin-bottom: 0px;}.uagb-block-3ee00f6a .uagb-infobox__content-wrap .uagb-ifb-separator{width: 30%;border-top-width: 2px;border-top-color: #333;border-top-style: solid;}.uagb-block-3ee00f6a .uagb-ifb-align-icon-after{margin-left: 5px;}.uagb-block-3ee00f6a .uagb-ifb-align-icon-before{margin-right: 5px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content svg{box-sizing: content-box;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content img{box-sizing: content-box;}.uagb-block-3ee00f6a .uagb-infobox__content-wrap{text-align: left;}.uagb-block-3ee00f6a.uagb-infobox-icon-above-title{text-align: left;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg {margin-left: 5px;}[dir=rtl] .uagb-block-3ee00f6a .uagb-iconbox-icon-wrap{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap > svg{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-icon-wrap > svg{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap img{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-right-title-image > img{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-left-title-image > img{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content > img{padding-right: 0px;padding-left: 0px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap{text-align: right;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox-icon-above-title{text-align: right;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg{margin-right: 5px;margin-left: 0px;}@media only screen and (max-width: 976px) {.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap > svg{width: 30px;height: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-icon-wrap > svg{line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content img{box-sizing: content-box;}.uagb-block-3ee00f6a .uagb-ifb-icon{width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-ifb-icon > span{font-size: 30px;width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-iconbox-icon-wrap{width: 30px;height: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-left-title-image > svg{width: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-right-title-image > svg{width: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg {margin-left: 5px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg{margin-right: 5px;margin-left: 0px;}}@media only screen and (max-width: 767px) {.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-icon-wrap > svg{width: 30px;height: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content .uagb-ifb-icon-wrap > svg{line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-left-title-image > svg{width: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a .uagb-ifb-content .uagb-ifb-right-title-image > svg{width: 30px;line-height: 30px;font-size: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-ifb-content img{box-sizing: content-box;}.uagb-block-3ee00f6a .uagb-ifb-icon{width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-ifb-icon > span{font-size: 30px;width: 30px;line-height: 30px;}.uagb-block-3ee00f6a .uagb-iconbox-icon-wrap{width: 30px;height: 30px;line-height: 30px;}.uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg {margin-left: 5px;}[dir=rtl] .uagb-block-3ee00f6a.uagb-infobox__content-wrap .uagb-infobox-cta-link > svg{margin-right: 5px;margin-left: 0px;}}\";s:2:\"js\";s:0:\"\";s:18:\"current_block_list\";a:8:{i:0;s:13:\"uagb\/info-box\";i:1;s:10:\"core\/image\";i:2;s:12:\"core\/heading\";i:3;s:14:\"core\/paragraph\";i:4;s:11:\"core\/search\";i:5;s:14:\"uagb\/separator\";i:6;s:18:\"uagb\/taxonomy-list\";i:7;s:13:\"core\/archives\";}s:8:\"uag_flag\";b:1;s:11:\"uag_version\";s:10:\"1770034961\";s:6:\"gfonts\";a:0:{}s:10:\"gfonts_url\";s:0:\"\";s:12:\"gfonts_files\";a:0:{}s:14:\"uag_faq_layout\";b:0;}"],"_uag_css_file_name":["uag-css-21280.css"]},"uagb_featured_image_src":{"full":["https:\/\/www.opc.cat\/wp-content\/uploads\/2013\/08\/memoria-11.jpeg",225,225,false],"thumbnail":["https:\/\/www.opc.cat\/wp-content\/uploads\/2013\/08\/memoria-11-150x150.jpeg",150,150,true],"medium":["https:\/\/www.opc.cat\/wp-content\/uploads\/2013\/08\/memoria-11.jpeg",225,225,false],"medium_large":["https:\/\/www.opc.cat\/wp-content\/uploads\/2013\/08\/memoria-11.jpeg",225,225,false],"large":["https:\/\/www.opc.cat\/wp-content\/uploads\/2013\/08\/memoria-11.jpeg",225,225,false],"1536x1536":["https:\/\/www.opc.cat\/wp-content\/uploads\/2013\/08\/memoria-11.jpeg",225,225,false],"2048x2048":["https:\/\/www.opc.cat\/wp-content\/uploads\/2013\/08\/memoria-11.jpeg",225,225,false]},"uagb_author_info":{"display_name":"opc","author_link":"https:\/\/www.opc.cat\/es\/author\/opc\/"},"uagb_comment_info":0,"uagb_excerpt":"M\u00e1s all\u00e1 del Alzheimer, existe un hecho fisiol\u00f3gico que es pr\u00e1cticamente inevitable. Con la vejez, se va perdiendo la memoria y de ah\u00ed las preguntas reiteradas y el no retener cosas que antes se manten\u00edan en la mente sin tener que hacer ning\u00fan esfuerzo. No es algo que solo le ocurra a los humanos, tambi\u00e9n&hellip;","_links":{"self":[{"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/posts\/21280","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/comments?post=21280"}],"version-history":[{"count":0,"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/posts\/21280\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/media\/24602"}],"wp:attachment":[{"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/media?parent=21280"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/categories?post=21280"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.opc.cat\/es\/wp-json\/wp\/v2\/tags?post=21280"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}