{"id":21286,"date":"2013-08-14T13:24:00","date_gmt":"2013-08-14T11:24:00","guid":{"rendered":"https:\/\/www.opc.cat\/identificadas-20-causas-geneticas-de-los-canceres-mas-comunes-2\/"},"modified":"2013-08-14T13:24:00","modified_gmt":"2013-08-14T11:24:00","slug":"identificadas-20-causas-geneticas-de-los-canceres-mas-comunes-2","status":"publish","type":"post","link":"https:\/\/www.opc.cat\/es\/identificadas-20-causas-geneticas-de-los-canceres-mas-comunes-2\/","title":{"rendered":"Identificadas 20 causas gen\u00e9ticas de los c\u00e1nceres m\u00e1s comunes"},"content":{"rendered":"<div class=\"separator\" style=\"clear: both; text-align: center;\">\n<a href=\"http:\/\/1.bp.blogspot.com\/-z9mzk35qsTA\/UiCeaunsCJI\/AAAAAAAAAGo\/_97_Md8Z0lI\/s1600\/investigacio%CC%81n-oncologia.jpg\" imageanchor=\"1\" style=\"clear: left; float: left; margin-bottom: 1em; margin-right: 1em;\"><img fetchpriority=\"high\" decoding=\"async\" border=\"0\" height=\"320\" src=\"https:\/\/www.opc.cat\/wp-content\/uploads\/2013\/08\/investigacio\u0301n-oncologia.jpg\" width=\"234\" \/><\/a><\/div>\n<div class=\"p1\">\nTodos los c\u00e1nceres se deben a mutaciones som\u00e1ticas: alteraciones gen\u00e9ticas que por lo general no han sido heredadas, sino que han ocurrido en las c\u00e9lulas del individuo a lo largo de su vida. Una cuesti\u00f3n crucial es entender qu\u00e9 provoca esas mutaciones, y un consorcio cient\u00edfico internacional da hoy un gran paso al identificar 20 firmas mutacionalesdistintas en los c\u00e1nceres humanos. Cada una de ellas representa un tipo de mecanismo responsable de generar las alteraciones gen\u00e9ticas, y su conocimiento \u201crevela la diversidad de los procesos mutacionales que subyacen al desarrollo del c\u00e1ncer\u201d, seg\u00fan los cient\u00edficos, y tiene implicaciones para la prevenci\u00f3n y el tratamiento de este azote sanitario.<\/div>\n<div class=\"p2\">\n<\/div>\n<div class=\"p1\">\nAlgunas de esas firmas, o procesos mutacionales, est\u00e1n presentes en muchos tipos de c\u00e1ncer, y otras son espec\u00edficas de una clase u otra de tumor. Adem\u00e1s, algunos de estos mecanismos de alteraci\u00f3n gen\u00e9tica se deben a la edad, otros a defectos en los sistemas de reparaci\u00f3n y mantenimiento gen\u00f3mico, y otros a mut\u00e1genos ambientales como el tabaco (en el c\u00e1ncer de pulm\u00f3n) o la luz ultravioleta (en el c\u00e1ncer de piel). Los datos tambi\u00e9n han revelado en muchos tipos de c\u00e1ncer peque\u00f1as regiones de ADN que sufren hipermutaci\u00f3n, un grado de alteraci\u00f3n muy superior al del resto del genoma.<\/div>\n<div class=\"p2\">\n<b><br \/><\/b><\/div>\n<div class=\"p3\">\n<b>Algunos procesos mutacionales son compartidos por muchos tumores<\/b><\/div>\n<div class=\"p4\">\n<\/div>\n<div class=\"p1\">\nEl consorcio implica a investigadores de 14 pa\u00edses y ha sido coordinado por Michael Stratton y sus colegas del Instituto Sanger, en Hinxton, Reino Unido. La contribuci\u00f3n espa\u00f1ola est\u00e1 liderada por El\u00edas Campo, del Hospital Cl\u00ednic-IDIBAPS y la Universidad de Barcelona, y Carlos L\u00f3pez-Ot\u00edn, del Instituto de Oncolog\u00eda de la Universidad de Oviedo. Se trata de un trabajo exhaustivo en que los cient\u00edficos han analizado el genoma de 7.042 tumores de todo tipo, que en total contienen nada menos que 5 millones de mutaciones.Con esos n\u00fameros, resulta verdaderamente notable que hayan podido reducir los mecanismos responsables a solo esas 20 firmas mutacionales distintas. De hecho, algunos tipos de c\u00e1ncer solo presentan dos firmas, lo que implica que solo hay dos mecanismos mutacionales implicados en su g\u00e9nesis. Otros tumores m\u00e1s complejos llegan a mostrar hasta seis firmas. En total, los cient\u00edficos han examinado los 30 tipos de c\u00e1ncer m\u00e1s comunes.<\/div>\n<div class=\"p2\">\n<\/div>\n<div class=\"p1\">\nUn buen ejemplo de c\u00f3mo se ha distribuido el trabajo entre el consorcio es la contribuci\u00f3n espa\u00f1ola, que se ha centrado en un centenar de genomas de un tipo concreto de c\u00e1ncer, la leucemia linf\u00e1tica cr\u00f3nica. Los resultados han revelado que este tumor de las c\u00e9lulas de la sangre se genera mediante dos procesos fundamentales, uno debido a la edad y otro a deficiencias en los mecanismos de reparaci\u00f3n del ADN. Como los da\u00f1os en el material gen\u00e9tico son constantes durante la vida, nuestra supervivencia depende en realidad de la acci\u00f3n continua de esos procesos de reparaci\u00f3n y mantenimiento del genoma; cuando fallan, las mutaciones espont\u00e1neas se acumulan con resultados fatales.<\/div>\n<div class=\"p2\">\n<\/div>\n<div class=\"p1\">\n\u201cSin la estrecha colaboraci\u00f3n internacional de todos los grupos de trabajo implicados en el proyecto\u201d, dice L\u00f3pez-Ot\u00edn, \u201chabr\u00eda sido imposible obtener estos importantes resultados\u201d. Campo a\u00f1ade: \u201cEstamos ante uno de los primeros ejemplos de la nueva visi\u00f3n que puede ofrecer la secuenciaci\u00f3n masiva y coordinada de genomas a trav\u00e9s del Consorcio Internacional del Genoma del C\u00e1ncer\u201d. En estos tiempos de cicater\u00eda presupuestaria, es justo a\u00f1adir que la parte espa\u00f1ola del proyecto ha sido financiada por el Ministerio de Econom\u00eda.<\/div>\n<div class=\"p2\">\n<\/div>\n<div class=\"p1\">\nUno de los fen\u00f3menos m\u00e1s peculiares que ha revelado el trabajo internacional son las peque\u00f1as zonas del genoma que sufren unas tasas de mutaci\u00f3n anormalmente altas (hipermutaci\u00f3n). Los cient\u00edficos las han denominado kataegis, por la palabra griega que significa tormenta. No se trata de que los cromosomas se rompan o se barajen: las mutaciones que ocurren all\u00ed son tan puntuales (cambios de una letra del ADN por otra) como las que ocurren en el resto del genoma, solo que ocurren a una tasa tormentosa: hasta varios miles de mutaciones en un peque\u00f1o espacio.<\/div>\n<div class=\"p2\">\n<\/div>\n<div class=\"p1\">\nAunque las kataegis, o tormentas de mutaciones, no consistan por s\u00ed mismas en roturas cromos\u00f3micas, s\u00ed que suelen ocurrir en la vecindad de una de ellas. Las zonas concretas donde ocurren \u2014tanto la reorganizaci\u00f3n cromos\u00f3mica como la tormenta de mutaciones puntuales\u2014 son bastante reproducibles en cada tipo de c\u00e1ncer, pero var\u00edan entre tipos. Las kataegis son comunes en el c\u00e1ncer de mama (donde de hecho se descubrieron), p\u00e1ncreas, pulm\u00f3n, h\u00edgado, meduloblastoma, linfoma de c\u00e9lulas B y leucemia linfobl\u00e1stica aguda.<\/div>\n<div class=\"p2\">\n<\/div>\n<div class=\"p3\">\n<b>Unos se deben a la edad, otros a defectos gen\u00f3micos y otros al ambiente<\/b><\/div>\n<div class=\"p4\">\n<\/div>\n<div class=\"p1\">\nUn fen\u00f3meno vagamente similar a estas tormentas de mutaciones ocurre durante la maduraci\u00f3n normal de los linfocitos, las c\u00e9lulas blancas de la sangre que producen los anticuerpos y otras prote\u00ednas especializadas en reconocer agentes extra\u00f1os al cuerpo. Puesto que estos agentes pat\u00f3genos son potencialmente infinitos, los genes de los anticuerpos utilizan una variedad de mecanismos para generar una variedad igualmente indefinida de especificidades, y la hipermutaci\u00f3n \u2014controlada y restringida a ciertas zonas muy concretas del gen\u2014 es uno de sus principales recursos. De hecho, las kataegis en los c\u00e1nceres de los linfocitos, como los linfomas, tienden a ocurrir en los genes de las inmunoglobulinas, los componentes de los anticuerpos. En otros c\u00e1nceres no es as\u00ed, sin embargo.<\/div>\n<div class=\"p2\">\n<\/div>\n<p><\/p>\n<div class=\"p1\">\n\u201cEs probable que se descubran m\u00e1s firmas mutacionales\u201d, reconocen Stratton y sus colegas en el art\u00edculo principal sobre el asunto en Nature, \u201cjunto a una definici\u00f3n m\u00e1s precisa de sus caracter\u00edsticas, a medida que el n\u00famero que c\u00e1nceres con el genoma secuenciado se incremente y los m\u00e9todos anal\u00edticos se vayan refinando\u201d. Los cient\u00edficos no pretenden haber hallado todos los procesos responsables de las mutaciones del c\u00e1ncer, aunque s\u00ed creen haber dado con la mayor\u00eda de ellos.<\/div>\n<div class=\"p1\" style=\"text-align: right;\">\n<i>Fuente: <a href=\"http:\/\/sociedad.elpais.com\/sociedad\/2013\/08\/14\/actualidad\/1376498769_558828.html\" target=\"_blank\">El Pa\u00eds<\/a><\/i><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Todos los c\u00e1nceres se deben a mutaciones som\u00e1ticas: alteraciones gen\u00e9ticas que por lo general no han sido heredadas, sino que han ocurrido en las c\u00e9lulas del individuo a lo largo de su vida. Una cuesti\u00f3n crucial es entender qu\u00e9 provoca esas mutaciones, y un consorcio cient\u00edfico internacional da hoy un gran paso al identificar 20 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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